摘要
目的分析黄芪注射液联合非奈利酮片对Ⅲ~Ⅳ期糖尿病肾病治疗效果及对患者肾功能及氧化应激指标的影响。方法本研究采用回顾性研究方法,选取2023年1月至2025年1月永城市人民医院收治的90例Ⅲ~Ⅳ期糖尿病肾病患者为研究对象,按照不同治疗方法进行分组,以非奈利酮片治疗的43例列为对照组,在此基础上联合黄芪注射液治疗的47例列为研究组。比较两组治疗效果、肾功能[血肌酐(SCR)、24 h尿蛋白定量(24 hUTP)、尿白蛋白/肌酐(UACR)]、氧化应激指标[谷胱甘肽过氧化物酶(GSH-Px)、超氧化物歧化酶(SOD)、丙二醛(MDA)]及不良反应。结果与对照组(76.74%)相比,研究组治疗总有效率(93.62%)较高(P<0.05)。治疗4周后,研究组SCR、24 hUTP、UACR水平低于对照组(P<0.05);研究组SOD、GSH-Px水平高于对照组,MDA水平低于对照组(P<0.05)。两组不良反应总发生率比较(12.77%vs 11.63%),差异无统计学意义(P>0.05)。结论Ⅲ~Ⅳ期糖尿病肾病患者经黄芪注射液联合非奈利酮片治疗能提高治疗效果,促进肾功能恢复,减轻氧化应激反应,延缓病情进展。
Objective To analyze the therapeutic effect of astragalus injection combined with finerenone tablets in the treatment of stageⅢ-Ⅳdiabetic nephropathy and its influence on renal function and oxidative stress index.Methods A retrospective study method was used in this study,a total of 90 patients with stageⅢ-Ⅳdiabetic nephropathy admitted to Yongcheng People's Hospital from January 2023 to January 2025 were selected as the study subjects.The patients were grouped according to different treatment methods,43 patients treated with finerenone tablets were classified as the control group,and 47 patients treated with astragalus injection on this basis were classified as the study group.The therapeutic effect and adverse reactions were compared between the two groups,as well as the renal function[serum creatinine(SCR),24-hour urinary protein quantification(24 hUTP),urinary albumin to creatinine ratio(UACR)],oxidative stress indexes[glutathione peroxidase(GSH-Px),superoxide dismutase(SOD),malondialdehyde(MDA)].Results Compared with the control group(76.74%),the total effective rate of treatment in the study group(93.62%)was higher(P<0.05).After 4 weeks of treatment,the levels of SCR,24 hUTP and UACR in the study group were lower than those in the control group(P<0.05);the levels of SOD and GSH-Px in the study group were higher than those in the control group,and the level of MDA was lower than that in the control group(P<0.05).No statistically significant difference was found in the total incidence of adverse reactions between the two groups(12.77%vs 11.63%)(P>0.05).Conclusion The treatment of patients with stageⅢ-Ⅳdiabetic nephropathy by astragalus injection combined with finerenone tablets can improve the therapeutic effect,promote the recovery of renal function,reduce oxidative stress response,and delay the progression of the disease.
作者
王静
魏新平
赵明
WANG Jing;WEI Xinping;ZHAO Ming(Yongcheng People's Hospital,Yongcheng Henan 476600,China;The First People's Hospital of Shangqiu,Shangqiu Henan 476100,China)
出处
《药品评价》
2025年第12期1552-1555,共4页
Drug Evaluation
关键词
非奈利酮片
糖尿病肾病
黄芪注射液
肾功能
氧化应激
Finerenone tablets
Diabetic nephropathy
Astragalus injection
Renal function
Oxidative stress
