摘要
创伤后应激障碍(PTSD)是一种由创伤事件引发的心理障碍。近年来,神经影像学和遗传学研究为PTSD的病理机制提供了新的视角。结构磁共振成像发现,PTSD患者在海马、杏仁核和前额叶等脑区存在显著的结构性异常。功能磁共振成像则揭示,PTSD患者的大脑网络功能连接失调。弥散张量成像显示,PTSD患者的白质微结构发生改变。此外,遗传学研究发现,特定基因变异与PTSD的易感性相关。本文综述了近年来PTSD的影像学与遗传学研究,探讨了其在PTSD发病机制中的重要作用,并对未来研究方向提出了建议,为深入理解PTSD的神经生物学机制提供了新的视角。
Post-traumatic stress disorder(PTSD)is a psychological disorder triggered by traumatic events.In recent years,neuroimaging and genetic studies have provided new perspectives on the pathological mechanisms of PTSD.Structural magnetic resonance imaging(MRI)has revealed significant structural abnormalities in brain regions such as the hippocampus,amygdala,and prefrontal cortex in individuals with PTSD.Functional MRI has shown that PTSD patients exhibited disrupted brain network connectivity.Diffusion tensor imaging(DTI)further demonstrated alterations in the white matter microstructure of PTSD patients.Additionally,genetic studies have identified specific gene variants associated with susceptibility to PTSD.This review summarises recent neuroimaging and genetic research on PTSD,explores their important roles in the pathogenesis of the disorder,and provides suggestions for future research directions,offering new insights into the neurobiological mechanisms underlying PTSD.
作者
于士静
徐静文
Yu Shijing;Xu Jingwen(Shanghai NO.3 Civil Mental Health Center,Shanghai 200435,China)
出处
《中华行为医学与脑科学杂志》
北大核心
2026年第2期181-186,共6页
Chinese Journal of Behavioral Medicine and Brain Science
基金
上海市民政局科研课题(3-2-56)。
关键词
创伤后应激障碍
结构磁共振成像
功能磁共振成像
弥散张量成像
遗传学研究
Post-traumatic stress disorder
Structural magnetic resonance imaging
Functional magnetic resonance imaging
Diffusion tensor imaging
Genetic studies
