摘要
目的基于脑-肠轴理论,观察“足三里、血海”埋线联合调神通络针法治疗脑卒中后认知功能障碍(post-stroke cognitive impairment,PSCI)的临床疗效。方法采用随机数字表法将符合纳入标准的102例PSCI患者按照1∶1分为对照组和观察组,每组51例。前者按照常规西药治疗加认知功能训练,后者在对照组的基础上添加“足三里、血海”埋线联合调神通络针法治疗PSCI患者。两组患者均治疗8周。记录两组患者临床疗效例数和不良反应例数,比较两组患者治疗前后的5-羟色胺(5-hydroxytryptamine,5-HT)水平、蒙特利尔认知评估量表(Montreal cognitive assessment,MoCA)评分、洛文斯顿作业治疗认知评定成套测验(Loewenstein occupational therapy cognition assessment,LOTCA)评分、改良Barthel指数(Modified Barthel index,MBI)以及血清学指标血管内皮生长因子(vascular endothelial growth factor,VEGF)、血清脑源性神经营养因子(brain-derived neurotrophic factor,BDNF)水平。结果两组患者在接受治疗后,观察组患者有效率为92.16%(47/51),高于对照组70.59%(36/51),差异具有统计学意义(P<0.05)。两组患者在治疗期间均无不良反应发生。观察组患者在接受埋线联合针刺治疗后,5-HT水平、MoCA评分、LOTCA评分、MBI评分改善程度优于对照组(P<0.05)。较对照组而言,观察组VEGF水平提高程度高于对照组(P<0.05);BDNF水平低于对照组(P<0.05)。结论观察“足三里、血海”埋线联合调神通络针法治疗PSCI患者有良好的临床疗效,且安全性较高,值得推广。
Objective Based on the brain-gut axis theory,to observe the clinical efficacy of“Zusanli(ST36),Xuehai(SP10)”catgut embedding combined with the mind-regulating and collateral-dredging acupuncture in the treatment of post-stroke cognitive impairment(PSCI).Methods A total of 102 patients with PSCI who met the inclusion criteria were divided into a control group and an observation group according to 1∶1 by using the random number table method,with 51 patients in each group.The former group was treated with conventional western medicine and cognitive function training,while the latter group was additionally treated with“Zusanli(ST36),Xuehai(SP10)”catgut embedding combined with mind-regulating and collateral-dredging acupuncture for the treatment of PSCI patients on the basis of the control group.The patients in both groups were treated for 8 weeks.The number of clinical outcomes and the number of adverse reactions of both groups were recorded.The 5-hydroxytryptamine(5-HT)levels,Montreal cognitive assessment(MoCA)score,Loewenstein occupational therapy cognition assessment(LOTCA)score,Modified Barthel index(MBI)and serological indexes[vascular endothelial growth factor(VEGF)and brain-derived neurotrophic factor(BDNF)]before and after treatment in both groups were compared.Results After treatment,the effective rate in the observation group was 92.16%(47/51),higher than that[70.59%(36/51)]in the control group,and the difference was statistically significant(P<0.05).No adverse effects occurred during the treatment in either group.The patients in the observation group showed better improvement in 5-HT levels,MoCA score,LOTCA score and MBI score than the control group after receiving catgut embedding combined with acupuncture treatment(P<0.05).Compared with those of the control group,the VEGF level of the observation group was increased to a higher degree than that of the control group(P<0.05).The BDNF level was lower than that of the control group(P<0.05).Conclusion It is worthwhile to observe the good clinical efficacy and high safety of the treatment of PSCI patients with“Zusanli(ST36),Xuehai(SP10)”catgut embedding combined with mind-regulating and collateral-dredging acupuncture,which is worthy of popularisation.
作者
张晨茜
陈迎年
刘雪
汤瑶
潘娜
储浩然
ZHANG Chenxi;CHEN Yingnian;LIU Xue;TANG Yao;PAN Na;CHU Haoran(Anhui Wannan Rehabilitation Hospital(The Fifth People′s Hospital of Wuhu),Wuhu 241000,Anhui,China;The Second Affiliated Hospital of Anhui University of Chinese Medicine(Acupuncture and Moxibustion Hospital of Anhui Province),Hefei 230000,Anhui,China)
出处
《辽宁中医杂志》
北大核心
2026年第3期173-177,共5页
Liaoning Journal of Traditional Chinese Medicine
基金
安徽省中医药传承创新科研项目(2024CCCX075)
安徽省临床医学研究转化专项(202304295107020091)。
关键词
穴位埋线
调神通络
针刺
脑卒中后认知功能障碍
acupoint catgut embedding
regulating mind and dredging collateral
acupuncture
cognitive dysfunction after stroke
