摘要
目的:探讨经颅直流电刺激(tDCS)联合醒脑开窍针刺法治疗卒中后认知障碍的临床疗效。方法:采用随机数字表法将150例卒中后认知障碍患者随机分为联合组、针刺组、tDCS组,每组各50例。所有患者均接受常规药物治疗(盐酸多奈哌齐5 mg/d+盐酸美金刚5 mg/d)及认知功能训练。联合组在常规治疗基础上加用tDCS联合醒脑开窍针刺法;针刺组加用醒脑开窍针刺法;tDCS组加用tDCS。治疗28 d后采用MMSE、MoCA、Rivermead行为记忆功能、FIM及ADL评分评估三组疗效。结果:治疗前三组各项评分差异无统计学意义(P>0.05),治疗后联合组MMSE、MoCA、Rivermead行为记忆功能、FIM及ADL评分显著优于针刺组和tDCS组(P<0.01)。结论:tDCS联合醒脑开窍针刺法可显著改善卒中后认知功能,疗效优于单纯使用醒脑开窍针刺法和单独使用tDCS。
Objective To investigate the clinical efficacy of transcranial direct current stimulation(tDCS)combined with acupuncture for awakening the brain and opening the orifices(XNKQ)in the treatment of cognitive impairment after stroke.Methods A total of 150 patients diagnosed with cognitive impairment after stroke were assigned to three groups using a random number table method:combination group,acupuncture group,and tDCS group,with 50 cases in each group.All participants received standard pharmacological treatment(donepezil hydrochloride 5 mg/d+memantine hydrochloride 5 mg/d)and underwent cognitive function training.In addition to basic treatment,the combination group received tDCS combined with XNKQ;the acupuncture group was treated with XNKQ;the tDCS group was given tDCS alone.The therapeutic effects across the three groups were evaluated after 28 d of intervention using the Mini-Mental State Examination(MMSE),Montreal Cognitive Assessment(MoCA),Rivermead Behavioral Memory Test,Functional Independence Measure(FIM),and Activities of Daily Living(ADL)scores.Results No differences were observed in the scores among the three groups before treatment(P>0.05).After treatment,the combination group demonstrated more improvements in MMSE,MoCA,Rivermead behavioral memory function,FIM,and ADL scores than both acupuncture group and tDCS group(P<0.01).Conclusion The combination of tDCS and XNKQ significantly enhances cognitive function in post-stroke patients and has superior efficacy compared with XNKQ or tDCS alone.
作者
魏秀丽
艾钰
王德利
WEI Xiu-li;AI Yu;WANG De-li(Department of Rehabilitation Medicine,Renmin Hospital,Hubei University of Medicine,Shiyan,Hubei 442000,China)
出处
《湖北医药学院学报》
2026年第1期72-76,共5页
Journal of Hubei University of Medicine
关键词
卒中后认知障碍
经颅直流电
醒脑开窍针刺法
Post-stroke cognitive impairment
Transcranial direct current stimulation
Acupuncture for awakening the brain and opening the orifices(XNKQ)
