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槲皮素的结构修饰及其生物活性研究进展

Research Progress on Structural Modification and Biological Activity of Quercetin
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摘要 槲皮素是分布于洋葱、绿茶、苹果皮等常见食物中的类黄酮化合物,槲皮素的结构特殊赋予自身抗氧化、抗菌、抗炎、调节血糖、昼夜节律调节等多种生物活性。针对槲皮素水溶性低、化学稳定性差、生物利用率低的特点,使用化学修饰、生物修饰、纳米载体修饰等方法对槲皮素的结构进行修饰,并研究槲皮素及其衍生物的生物活性。目前,槲皮素及其衍生物在医药、畜禽和功能性食品领域均有较好的应用前景,可为槲皮素的深度开发利用提供理论参考。 Quercetin,a flavonoid commonly found in foods such as onions,green tea,and apple peels,possesses unique structural characteristics that endow it with various biological activities,including antioxidant,antibacterial,anti-inflammatory,blood glucose regulation,and circadian rhythm regulation.Given quercetin's low water solubility,poor chemical stability,and low bioavailability,methods such as chemical modification,biological modification,and nano-carrier modification have been employed to alter its structure,and the biological activities of quercetin and its derivatives had been studied.Currently,quercetin and its derivatives showed promising application prospects in the pharmaceutical,livestock and poultry production,and functional food sectors,providing theoretical references for the in-depth development and utilization of quercetin.
作者 赵文红 邓婉柔 温嘉裕 赵宏伟 费永涛 姜浩 ZHAO Wenhong;DENG Wanrou;WEN Jiayu;ZHAO Hongwei;FEI Yongtao;JIANG Hao(College of Light Industry and Food science,Zhongkai University of Agriculture and Engineering,Guangzhou,Guangdong 510225,China;Guangdong Provincial Key Laboratory of Lingnan Specialty Food Science and Technology,Guangzhou,Guangdong 510225,China;Academy of Contemporary Agricultural Engineering Innovations,Zhongkai University of Agriculture and Engineering,Guangzhou,Guangdong 510225,China;Infinitus(China)Co.,Ltd.,Guangzhou,Guangdong 510405,China)
出处 《农产品加工》 2026年第3期89-95,共7页 Farm Products Processing
基金 国家自然科学基金项目(32201959) 林芝市科技计划项目(ZYYDDFZX2025-02) 广州市科技计划项目(2023B03J1307) “百千万工程”农村科技特派员项目(KTP20240971) 仲恺农业工程学院2024年研究生科技创新基金项目(KA24YY07025)。
关键词 槲皮素 衍生物 结构修饰 昼夜节律调节 生物活性 quercetin derivative structure modification circadian rhythm regulation biological activity
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