摘要
黏膜免疫反应迅速,具有局部和全身免疫优势,是防控疾病感染的关键。灵芝多糖包括β-(1→3)、β-(1→6)糖苷键构型及三螺旋三维构象,具有免疫增强活性,作为佐剂具有极大应用潜力,但在黏膜免疫中报道较少。本文通过知网、PubMed等数据库依据“灵芝多糖”“黏膜”“免疫佐剂”等关键词对近20年的相关文献进行了检索,阐述了黏膜免疫系统的组成和灵芝多糖对抗原呈递细胞、淋巴细胞等的激活效应,明确了其在肠、口腔等黏膜部位的免疫效应与机制,及其与纳米技术结合的应用前景,旨在为灵芝多糖在黏膜免疫上的研究提供借鉴。
Mucosal immune responses are rapid and offer both local and systemic immunological advantages,making them crucial for disease prevention.Ganoderma polysaccharides(GPs),which includeβ-(1→3)andβ-(1→6)glycosidic bond configurations and triple-helix three-dimensional structures,possess immunoenhancing activities and hold significant potential as adjuvants,yet their application in mucosal immunity has been less reported.This study systematically reviewed the literature from the past 20 years using databases such as CNKI and PubMed,with key words including“Ganoderma polysaccharides”,“mucosal”,and“immunoadjuvant”.The composition of the mucosal immune system and the activation effects of GPs on antigen-presenting cells and lymphocytes were examined,clarifying the immunological effects and mechanisms of GPs as adjuvants across various mucosal sites,including the intestine,oral cavity,stomach,and nasal passages.Additionally,the potential applications of GPs in combination with nanotechnology were discussed.This review aims to provide a theoretical basis for further research and application of GPs in mucosal immunity.
作者
翟哲
陶玲玲
刘旭菡
程永现
ZHAI Zhe;TAO Ling-ling;LIU Xu-han;CHENG Yong-xian(School of Pharmacy,Henan University of Chinese Medicine,Zhengzhou 450046,China;Guangdong Provincial Key Laboratory of Chinese Medicine Ingredients and Gut Microbiomics;Institute for Inheritance-Based Innovation of Chinese Medicine,Shenzhen University;Marshall Laboratory of Biomedical Engineering,Shenzhen University;School of Pharmacy,Shenzhen University Medical School,Shenzhen University,Shenzhen 518055,China;School of Basic Medical Sciences of Yunnan University of CM,Kunming 650500,China)
出处
《天然产物研究与开发》
北大核心
2026年第2期435-442,383,共9页
Natural Product Research and Development
基金
国家自然科学基金(82030115)
广东省基础与应用基础研究粤深联合基金(2023A1515110428)
深圳市医学研究专项(D2401001)。
关键词
灵芝
灵芝多糖
黏膜免疫
免疫佐剂
Ganoderma
Ganoderma polysaccharides
mucosal immunity
immunoadjuvant
