摘要
沙眼衣原体感染已成为全球重要的公共卫生问题。Pgp3是由隐蔽性质粒编码的毒力蛋白,具有高度保守的三聚体结构,通过中和抗菌肽LL-37和激活TNFR1通路在沙眼衣原体致病过程中发挥关键作用。Pgp3蛋白作为免疫优势蛋白,基于Pgp3的血清学检测方法(ELISA/MBA/LISA)显著优于传统MOMP检测。其抗体可持续存在12年以上,是评估既往感染的理想标志物。与输卵管不孕症(aOR=2.6)和盆腔炎(PR=2)显著相关,具有预测深部感染的潜力。本综述系统分析沙眼衣原体Pgp3蛋白结构、致病机制及其抗体评估既往感染和预测深部感染中的应用,为Pgp3在沙眼衣原体感染的预后评估中的临床应用提供理论依据。
Chlamydia trachomatis infection has become a major global public health concern.Pgp3,a virulence protein encoded by a cryptic plasmid,features a highly conserved trimeric structure and plays a pivotal role in C.trachomatis pathogenesis by neutralizing the antimicrobial peptide LL-37 and activating the TNFR1 signaling pathway.As an immunodominant protein,Pgp3-based serological assays(ELISA/MBA/LISA)demonstrate significantly superior performance compared to traditional MOMP detection.Pgp3 antibodies persist for over 12 years,making them ideal markers for assessing past infections.Furthermore,Pgp3 seropositivity is significantly associated with tubal infertility(aOR=2.6)and pelvic inflammatory disease(PR=2.0),highlighting its potential for predicting deep-tissue infections.This review systematically analyzes the structure of the Pgp3 protein,its pathogenic mechanisms,and the application of its antibodies in evaluating past infections and predicting deep infections,thereby providing a theoretical foundation for prognostic evaluation of C.trachomatis infections.
作者
周涵
陈文韬
陈洋
张自岩
郑和平
ZHOU Han;CHEN Wentao;CHEN Yang;ZHANG Ziyan;ZHENG Heping(Dermatology Hospital,Southern Medical University,Southern Medical University,Guangzhou 510091,China;Guangzhou Key Laboratory of Precise Prevention and Control of Sexually Transmitted Diseases,Southern Medical University,Guangzhou 510091,China;Institute for Global Health,Southern Medical University,Guangzhou 510091,China)
出处
《皮肤性病诊疗学杂志》
2025年第8期598-603,共6页
Journal of Diagnosis and Therapy on Dermato-venereology
基金
国家自然科学基金(81974307)。
关键词
沙眼衣原体
Pgp3
血清学检测
既往感染
深部感染
Chlamydia trachomatis
Pgp3
serological detection
previous infection
deep infection
