摘要
新生儿缺氧缺血性脑病(hypoxic-ischemic encephalopathy,HIE)是造成新生儿死亡和儿童致残的主要原因,严重影响患儿的生活质量,给社会和家庭带来了沉重的负担。西藏超高海拔地区常因海拔高、空气氧含量低,加上孕母体缺乏产前检查意识,致使新生儿HIE的发病率比平原高得多,窒息后缺氧的程度也更为严重。随着影像检查手段的不断发展,多模态磁共振扫描技术包括弥散加权成像、弥散张量成像、磁敏感加权成像、扩散峰度成像、静息态脑功能成像、动脉自旋标记成像等检查技术具有灵敏度高、特异性强、信号对比度高、反映脑组织代谢水平等优势,可以弥补常规MRI技术的不足,对早期诊断及鉴别新生儿脑病脑功能和判断预后具有广泛的应用前景。本文探索西藏超高海拔地区新生儿在缺氧状态下,将多模态磁共振检查技术应用于新生儿从出生到两岁的脑组织及脑功能变化的研究进展及临床应用进行综述,为西藏超高海拔地区新生儿的缺氧缺血性脑病提供及时的、强有力的评估及诊疗依据,旨将缺氧缺血性脑病对新生儿脑功能的影响降至最低。
Neonatal hypoxic-ischemic encephalopathy(HIE)is a major cause of neonatal death and childhood disability,significantly affecting the quality of life of affected children and imposing a heavy burden on society and families.In the ultra-high altitude regions of Xizang,due to high altitude,low oxygen content in the air,and a lack of prenatal care awareness among pregnant mothers,the incidence of neonatal HIE is much higher than in the plains,and the degree of hypoxia after asphyxia is also more severe.With the continuous development of imaging examination methods,multimodal magnetic resonance imaging techniques,including diffusion-weighted imaging,diffusion tensor imaging,susceptibilityweighted imaging,diffusion kurtosis imaging,resting-state brain function imaging,and proton magnetic resonance spectroscopy imaging,have advantages such as high sensitivity,strong specificity,high signal contrast,and the ability to reflect the metabolic level of brain tissue.These techniques can compensate for the shortcomings of conventional MRI technology and have a broad application prospect for early diagnosis and differentiation of neonatal brain diseases,as well as for predicting outcomes.This article reviews the research progress and clinical application of applying multimodal magnetic resonance imaging techniques to the study of brain tissue and brain function changes in neonates from birth to two years old in the ultra-high altitude regions of Xizang,aiming to provide timely and powerful assessment and treatment basis for neonatal hypoxic-ischemic encephalopathy in these regions,with the goal of minimizing the impact of hypoxic-ischemic encephalopathy on neonatal brain function.
作者
范强树
杨超
韩雨璇
李少龙
贡桑嘎吉
卢洋
FAN Qiang-shu;YANG-chao;HAN Yu-xuan;LI Shao-long;GONG Sang Ga-ji;LU Yang(Department of Radiology,People's Hospital of Nagqu City,Nagqu 852000,Xizang Autonomous Region,China;Department of Radiology,the First Affiliated Hospital of Dalian Medical University,Dalian 116000,Liaoning Province,China;Department of Radiology,the Second Affiliated Hospital of Dalian Medical University,Dalian 116000,Liaoning Province,China)
出处
《中国CT和MRI杂志》
2026年第2期191-194,共4页
Chinese Journal of CT and MRI
基金
2024年西藏自治区自然科学基金组团式援藏医学项目[XZ2024ZR-ZY112(Z)]。
关键词
磁共振成像
多模态
新生儿
缺血缺氧脑病
高原脑病
磁共振脑功能成像
Magnetic Resonance Imaging
Multimodal
Neonatal
Ischemic Hypoxic Encephalopathy
Plateau Encephalopathy
Magnetic Resonance Brain Function Imaging
