摘要
目的评估双歧杆菌三联活菌胶囊与康复新液协同治疗对腹部放疗患者的临床疗效。方法纳入2021年6月至2023年12月江西省人民医院收治的罹患直肠癌或宫颈癌且需接受腹部放射治疗的患者共80例,根据随机数字表法将受试者分配至观察组和对照组,每组40例,两组均在放射治疗的基础上,观察组给予双歧杆菌三联活菌胶囊联合康复新液灌肠,对照组仅给予康复新液保留灌肠。分析两组急性放射性肠炎(ARP)的发生率及分级、发生时间、炎症因子水平及免疫功能指标。结果两组患者均完成试验,观察组ARP发生率低于对照组,差异有统计学意义(P<0.05);观察组首次出现ARP平均时间长于对照组,差异有统计学意义(P<0.05);观察组ARP的持续时间短于对照组,差异无统计学意义(P>0.05);观察组放疗后白细胞介素(interleukin,IL)-6、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)表达水平高于放疗前,差异有统计学意义(P<0.05),对照组放疗后IL-6、IL-8、TNF-α表达水平高于放疗前,差异有统计学意义(P<0.05);观察组放疗后的CD8^(+)T和CD4^(+)/CD8^(+)低于放疗前,差异有统计学意义(P<0.001),对照组放疗后的CD4^(+)T、CD8^(+)T和CD4^(+)/CD8^(+)低于放疗前,差异有统计学意义(P<0.001);观察组放疗后的CD4^(+)T细胞、CD4^(+)/CD8^(+)高于对照组,差异有统计学意义(P<0.001),两组放疗后CD4^(+)/CD8^(+)低于放疗前,差异有统计学意义(P<0.001)。结论新型临床方案双歧杆菌三联活菌胶囊联合康复新液对ARP具有预防和治疗的作用,值得推广。
Objective To evaluate the clinical efficacy of bifid triple viable capsules combined with Kangfuxin liquid in patients receiving abdominal radiotherapy.Methods A total of 80 patients diagnosed with rectal or cervical cancer and undergoing abdominal radiotherapy at Jiangxi Provincial People′s Hospital from June 2021 to December 2023 were enrolled and randomly assigned into two groups(n=40 each)using a random number table.Both groups received standard radiotherapy;the observation group received additional treatment with bifid triple viable capsules and Kangfuxin liquid enema,while the control group received Kangfuxin liquid retention enema alone.The incidence,grade,and onset time of acute radiation enteritis(ARE),as well as inflammatory cytokine levels and immune function indices,were compared between the two groups.Results All patients completed the study.The incidence of ARE was significantly lower in the observation group than in the control group(P<0.05).The mean time to ARE onset was longer in the observation group(P<0.05),while the duration of ARE was shorter but not significantly different between groups(P>0.05).After radiotherapy,interleukin(IL)-6 and tumor necrosis factor-α(TNF-α)levels significantly increased in the observation group(P<0.05),whereas IL-6,IL-8,and TNF-αlevels all increased in the control group(P<0.05).Post-radiotherapy,CD8^(+)T cells and CD4^(+)/CD8^(+)ratios in the observation group decreased significantly compared with pre-radiotherapy(P<0.001),while CD4^(+)T,CD8^(+)T cells,and CD4^(+)/CD8^(+)ratios in the control group also declined significantly(P<0.001).Notably,CD4^(+)T cells and CD4^(+)/CD8^(+)ratios after radiotherapy were higher in the observation group compared with the control group(P<0.001).Both groups showed lower CD4^(+)/CD8^(+)ratios post-radiotherapy than before treatment(P<0.001).Conclusion The combined regimen of bifid triple viable capsules and Kangfuxin liquid demonstrates preventive and therapeutic benefits against acute radiation enteritis in patients undergoing abdominal radiotherapy,indicating potential for wider clinical application.
作者
胡猛
杨俊
罗毅君
姚伟荣
沈庆林
HU Meng;YANG Jun;LUO Yi-jun;YAO Wei rong;SHEN Qing-lin(Department of Oncology,Jiangxi Provincial People's Hospital,the First Affiliated Hospital of Nanchang Medical College,Nanchang 33OO06,Jiangxi,China)
出处
《广东医学》
2025年第11期1671-1675,共5页
Guangdong Medical Journal
基金
江西省中医药管理局科技计划项目(2021B003)。
关键词
腹部恶性肿瘤
放射治疗
双歧杆菌三联活菌制剂
急性放射性肠炎
康复新液
abdominal malignancy
radiation therapy
bifidobacterium bifidum triple live bacterial preparation
acute radiation enteritis
Kangfuxin liquid
