摘要
目的:分析益生菌制剂辅助治疗轻症胆源性急性胰腺炎的效果。方法:纳入2023年1月—2024年12月上饶市人民医院收治的104例轻症胆源性急性胰腺炎患者,随机分为参照组和观察组,各52例。参照组实施常规治疗,观察组在其基础上实施益生菌制剂(双歧杆菌三联活菌胶囊)治疗。比较两组恢复情况(腹痛缓解时间、开放饮食时间、住院时间)。比较两组治疗前、治疗1周后的炎症因子(IL-6、CRP、PCT)、血常规指标[WBC、血细胞比容(HCT)]、胰腺损伤相关指标[淀粉酶(AMY)、脂肪酶(LPS)、胰蛋白酶原激活肽(TAP)]。比较两组住院期间并发症[不完全性肠梗阻、全身炎症反应综合征(SIRS)、多器官功能障碍综合征(MODS)]总发生率,以及药物不良反应发生情况。结果:相较参照组,观察组腹痛缓解时间、开放饮食时间早,住院时间明显短(P<0.05)。治疗1周后,两组IL-6、CRP、PCT、WBC、HCT、AMY、LPS、TAP水平较治疗前显著降低,且观察组较参照组低(P<0.05)。两组住院期间并发症总发生率比较,差异无统计学意义(P>0.05)。两组患者治疗期间均未发生明显药物不良反应。结论:益生菌制剂辅助治疗轻症胆源性急性胰腺炎有利于抑制炎症反应,缓解胰腺损伤,促进患者恢复。
Objective:To analyze the effect of probiotic preparation in the adjuvant treatment of mild biliary acute pancreatitis.Method:A total of 104 patients with mild biliary acute pancreatitis admitted to Shangrac People's Hospital from January 2023 to December 2024 were included and randomly divided into a reference group and an observation group,with 52 cases in each group.The reference group received conventional treatment,and the observation group was treated with probiotic preparations(Liver Combined Bifidobacterium,Lactobacillus and Enterococcus Capsules)on this basis.The recovery conditions(abdominal pain relief time,resuming diet time,and hospital stay)of the two groups were compared.The inflammatory factors(IL-6,CRP,PCT),blood routine indicators[WBC,hematocrit(HCT)],and indicators related to pancreatic injury[amylase(AMY),lipase(LPS),trypsinogen activating peptide(TAP)]of the two groups before treatment and after one week of treatment were compared.The total incidence of complications during hospitalization[incomplete intestinal obstruction,systemic inflammatory response syndrome(SIRS),multiple organ dysfunction syndrome(MODS)]and the occurrence of adverse drug reactions were compared between the two groups.Result:Compared with the reference group,the abdominal pain relief time,resuming diet time in the observation group were earlier,and the hospital stay was significantly shorter(P<0.05).After one week of treatment,the levels of IL−6,CRP,PCT,WBC,HCT,AMY,LPS and TAP in thetwo groups were significantly lower than those before treatment,and those in the observation group were lower than those in the reference group(P<0.05).There was no significant difference in the total incidence of complications during hospitalization between the two groups(P>0.05).No obvious adverse drug reactions occurred in the two groups during treatment.Conclusion:Probiotic preparation in the adjuvant treatment of mild biliary acute pancreatitis is beneficial to inhibit inflammatory reaction,alleviating pancreatic injury,and promote the recovery of patients.
作者
杨静
胡玲珍
吴当彦
项志雄
魏倩
YANG Jing;HU Lingzhen;WU Dangyan;XIANG Zhixiong;WEI Qian(Department of Gastroenterology,Shangrao People's Hospital,Shangrao 334000,China;不详)
出处
《中国医学创新》
2025年第35期18-22,共5页
Medical Innovation of China
关键词
益生菌制剂
轻症胆源性急性胰腺炎
炎症因子
胰腺损伤
Probiotic preparation
Mild biliary acute pancreatitis
Inflammatory factors
Pancreatic injury
