摘要
目的:探究骨松宝颗粒联合经皮椎体成形术(PVP)对老年胸腰椎骨折患者的治疗效果及影像学指标、功能恢复的影响。方法:选取2021年7月~2024年12月某院收治的76例老年胸腰椎骨折患者,采用简单随机分组法分为PVP组和联合组,每组38例。PVP组予以PVP治疗,联合组在此基础上予以骨松宝颗粒治疗,疗程为3个月。比较两组康复进程(术后下床活动时间、骨折愈合时间、恢复正常活动时间及住院时间)、疼痛情况[视觉模拟评分法(VAS)]、腰椎功能[Oswestry功能障碍指数(ODI)]、影像学指标(伤椎Cobb角、椎体前缘高度、椎体中线高度)、骨密度(右股骨颈、L_(2)~L_(4)腰椎)及不良反应发生情况。结果:联合组骨折愈合时间和恢复正常活动时间均短于PVP组(P<0.05);两组术后下床活动时间和住院时间比较均无统计学差异(P>0.05)。术后3个月,两组VAS评分、ODI和伤椎Cobb角均降低,且联合组低于PVP组(P<0.05);椎体前缘高度、椎体中线高度、右股骨颈骨密度和L_(2)~L_(4)腰椎骨密度均升高,且联合组高于PVP组(P<0.05)。两组患者不良反应总发生率比较无统计学差异(P>0.05)。结论:骨松宝颗粒联合PVP治疗可有效减轻老年胸腰椎骨折患者疼痛,提高脊柱结构重建效果,增加骨密度,改善腰椎功能,且不增加不良反应的发生风险。
Objective:To investigate the effects of Gusongbao granules combined with percutaneous vertebroplasty(PVP)on clinical efficacy,radiographic parameters and functional recovery in elderly patients with thoracolumbar fractures.Methods:A total of 76 elderly patients with thoracolumbar fractures admitted to a hospital between July 2021 and December 2024 were selected and assigned to the PVP group and combination therapy group by simple random grouping method,with 38 patients in each group.The PVP group received PVP treatment,while the combination therapy group was treated with Gusongbao granules in addition to PVP.Both groups were treated for a period of three months.The rehabilitation process(postoperative time to ambulation,fracture healing time,time to resume normal activities,length of hospital stay),pain[visual analogue scale(VAS)],lumbar function[Oswestry Disability Index(ODI)],radiographic parameters(the Cobb angle of the injured vertebra,anterior vertebral height,mid-vertebral height),bone density(right femoral neck,lumbar spine L_(2)~L_(4))and adverse reactions were compared between the two groups.Results:The fracture healing time and time to resume normal activities in the combination therapy group were shorter than those in the PVP group(P<0.05).No statistically significant differences in postoperative time to ambulation and length of hospital stay were observed between the two groups(P>0.05).At 3 months post-surgery,the VAS scores,ODI and the Cobb angle of the injured vertebra decreased in both groups,with the combination therapy group showing lower values than the PVP group(P<0.05).The anterior vertebral height,mid-vertebral height and bone density(right femoral neck,lumbar spine L_(2)~L_(4))increased in both groups,with the combination therapy group showing higher values than the PVP group(P<0.05).No statistically significant difference in the total incidence of adverse reactions was observed between the two groups(P>0.05).Conclusion:Gusongbao granules combined with PVP in elderly patients with thoracolumbar fractures can effectively alleviate pain,enhance spinal structural reconstruction,increase bone density,and improve lumbar function,without increasing the risk of adverse reactions.
作者
燕勇
陈伟
高嵩涛
YAN Yong;CHEN Wei;GAO Song-tao(Zhengzhou Hospital of Traditional Chinese Medicine,Zhengzhou 450007,China;Henan Provincial People's Hospital,Zhengzhou 450000,China)
出处
《中国合理用药探索》
2025年第12期83-88,共6页
Chinese Journal of Rational Drug Use
基金
河南省二〇二四年科技发展计划项目(242102521062)。
关键词
胸腰椎骨折
老年
骨松宝颗粒
经皮椎体成形术
影像学指标
腰椎功能
thoracolumbar fractures
elderly
Gusongbao granules
percutaneous vertebroplasty
radiographic parameters
lumbar function
