摘要
目的:探讨骨松宝颗粒联合唑来膦酸对绝经后女性骨质疏松性胸腰压缩骨折(OVCF)患者的临床疗效及安全性。方法:选取2023年8月-2024年8月本院收治的270例绝经后女性OVCF患者,采用随机数字表法分为研究组和对照组,各135例。两组均接受经皮椎体成形术(PKP)治疗,术后对照组给予唑来膦酸静脉滴注(4mg溶于100ml 0.9%氯化钠溶液,滴注时间<15min,单次给药);研究组在对照组基础上加服骨松宝颗粒(10g/次,3次/天)。两组均连续治疗3个月,比较治疗前后骨密度(股骨颈、腰椎正位、大转子)、Oswestry功能障碍指数(ODI)、视觉模拟评分(VAS)、骨代谢指标[骨钙素(BGP)、骨保护素(OPG)]、血清炎性因子[白细胞介素-1β(IL-1β)、白细胞介素-17(IL-17)]及临床疗效、不良反应。结果:治疗前,两组上述指标比较均无统计学差异(P>0.05)。治疗后,两组股骨颈、腰椎正位、大转子骨密度,BGP、OPG水平均较治疗前升高,ODI评分、VAS评分,IL-1β、IL-17水平均较治疗前降低,且研究组较对照组升高/降低更明显,差异均有统计学意义(P<0.05)。研究组总有效率显著高于对照组(95.56%vs 87.41%,P<0.05)。两组不良反应发生率无统计学差异(P>0.05)。结论:骨松宝颗粒联合唑来膦酸可显著改善绝经后女性OVCF患者的腰椎功能、缓解术后疼痛、提高骨密度、调节骨代谢、降低炎性因子水平,且安全性良好。
Objective:To explore the clinical efficacy and safety of Gusongbao granules combined with Zoledronic acid in postmenopausal women with osteoporotic thoracolumbar compression fractures(OVCF).Method:A total of 270 postmenopausal female patients with OVCF admitted to our hospital from August 2023 to August 2024 were selected and divided into a study group and a control group using a random number table method,with 135 cases in each group.Both groups received percutaneous kyphoplasty(PKP).After the operation,the control group was given intravenous infusion of Zoledronic acid(4mg dissolved in 100ml of 0.9% sodium chloride solution,with an infusion time of<15min,single administration);the study group was given oral Gusongbao granules on the basis of the control group(10g each time,3 times a day).Both groups received continuous treatment for 3 months.Bone mineral density(femoral neck,lumbar spine anteroposterior position,greater trochanter),oswestry disability index(ODI),visual analogue scale(VAS),bone metabolism indicators[bone gla protein(BGP),osteoprotegerin(OPG)],serum inflammatory factors(IL-1β,IL-17),as well as clinical efficacy and adverse reactions were compared before and after treatment.Results:Before treatment,there were no statistically significant differences in the above indicators between the two groups(P>0.05).After treatment,the bone mineral density of the femoral neck,lumbar spine anteroposterior position,and greater trochanter,as well as the levels of BGP and OPG in both groups were higher than those before treatment;the ODI score,VAS score,and the levels of IL-1βand IL-17 were lower than those before treatment;and the increase/decrease in the study group was more significant than that in the control group,with statistically significant differences(P>0.05).The total effective rate of the study group was significantly higher than that of the control group(95.56%vs 87.41%,P>0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Gusongbao granules combined with Zoledronic acid can significantly improve lumbar function,relieve postoperative pain,increase bone mineral density,regulate bone metabolism,and reduce the levels of inflammatory factors in postmenopausal women with OVCF,with good safety.
作者
黄少波
潘德佳
朱毅
HUANG Shaobo;PAN Dejia;ZHU Yi(Department of Orthopedics,Chongqing Kaizhou District Traditional Chinese Medicine Hospital,Chongqing 405400,China;Department of Pharmacy,Chongqing Kaizhou District Traditional Chinese Medicine Hospital,Chongqing 405400,China;Department of Rehabilitation,Chongqing Kaizhou District Traditional Chinese Medicine Hospital,Chongqing 405400,China)
出处
《微循环学杂志》
2025年第3期28-33,共6页
Chinese Journal of Microcirculation
关键词
骨松宝颗粒
唑来膦酸
绝经后女性
骨质疏松性胸腰压缩骨折
疗效
Gusongbao granules
Zoledronic acid
Postmenopausal women
Osteoporotic thoracolumbar compression fractures
Efficacy
