摘要
慢性阻塞性肺疾病(简称慢阻肺病)是一种异质性肺部状态, 具有多种表型和内型, 其中, 肺气肿表型是慢阻肺病的重要表型之一, 主要表现为终末细支气管壁和肺泡的破坏, 与其他表型相比, 具有更严重的肺功能损害以及可能更严重的全身功能障碍。通过识别生物标志物、信号通路及影像学评估早期诊断肺气肿并开展肺气肿精准靶向治疗有益于患者预后。文章通过对近年来肺气肿表型慢阻肺病的病理学特征、生物标志物、信号通路及治疗理论进行综述, 以期提高对该表型的认识。
Chronic obstructive pulmonary disease(COPD)is a heterogeneous condition with diverse phenotypes and endotypes.The emphysema phenotype,characterized by destruction of the terminal bronchioles and alveolar walls,is associated with more severe lung function impairment,heightened airway inflammation,and greater systemic dysfunction compared to other subtypes.Early diagnosis via biomarkers,signaling pathway analysis,and imaging,combined with targeted therapies,may improve patient outcomes.However,further research is needed to fully elucidate this phenotype.This review summarizes recent advances in the pathology,biomarkers,signaling pathways,and clinical management of the emphysema phenotype of COPD,aiming to enhance its recognition and inform future research.
作者
武晓雪
刘先胜
王锐英
Wu Xiaoxue;Liu Xiansheng;Wang Ruiying(Third Hospital of Shanxi Medical University,Shanxi Bethune Hospital,Shanxi Academy of Medical Sciences,Tongji Shanxi Hospital,Taiyuan 030032,China;Department of Respiratory and Critical Care Medicine,Affiliated Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China)
出处
《中华全科医师杂志》
2025年第12期1569-1575,共7页
Chinese Journal of General Practitioners
基金
中华国际医学交流基金项目(Z-2017-24-2301)。
关键词
肺疾病
慢性阻塞性
肺气肿
疾病管理
Pulmonary disease,chronic obstructive
Emphysema
Disease management
