摘要
目的探讨糖皮质激素不同给药方式治疗慢性阻塞性肺疾病急性加重期(AECOPD)对肺功能及炎症因子的影响。方法选择2018年2月至2019年2月我院收治的AECOPD患者92例,采用随机数字表法分为两组,各46例。对照组给予甲泼尼龙片静脉滴注,观察组给予甲泼尼龙片口服,比较两组肺功能、炎症因子水平及不良反应。结果观察组治疗7 d后用力肺活量(FVC)、第1 s用力呼气量(FEV1)及FEV1/FVC略低于对照组;观察组治疗7 d后肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、血清C反应蛋白(CRP)水平略高于对照组,差异无统计学意义(P>0.05);观察组不良反应发生率低于对照组,差异有统计学意义(P<0.05)。结论采用口服或静脉滴注糖皮质激素治疗对AECOPD患者肺功能及炎症因子均有较好改善效果,但口服方式不良反应较少。
Objective To investigate the effects of different glucocorticoid administration on pulmonary function and inflammatory factors in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods 92 cases of AECOPD patients admitted to our hospital from February 2018 to February 2019 were selected and randomly divided into two groups,46 cases each.Prednisone was given orally to the control group and budesonide suspension was given atomized inhalation to the observation group.Lung function and inflammatory factor levels were compared between the two groups.Results After treatment,the forced vital capacity(FVC),forced expiratory capacity(FEV1)and FEV1/FVC in the observation group were all higher than those in the control group,with statistically significant differences(P<0.05).After treatment,the levels of Tumor Necrosis Factor(tnf-alpha),interleukin-6(il-6)and c-reactive protein(CRP)in the observation group were lower than those in the control group.Conclusion Nebulized glucocorticoid can improve pulmonary function and inflammatory factors in patients with AECOPD.
作者
段治伟
DUAN Zhi-wei(Intensive Care Unit,Songxian Hospital of Traditional Chinese Medicine,Luoyang city,Province 471400 China)
出处
《内蒙古医学杂志》
2020年第7期771-773,共3页
Inner Mongolia Medical Journal
关键词
慢性阻塞性肺疾病
糖皮质激素
肺功能
chronic obstructive pulmonary disease
Glucocorticoid
Lung function
