摘要
目的 分析牙列缺失患者血清C反应蛋白(CRP)、白细胞介素-6(IL-6)水平及与种植修复后发生种植体周围黏膜炎的关系。方法 选取2022年1月至2023年6月于南京大学医学院附属口腔医院完成种植修复治疗的120例牙列缺失患者作为研究对象,依据患者种植修复后是否发生种植体周围黏膜炎分为发生组和未发生组。采用酶联免疫吸附试验检测患者血清CRP、IL-6水平。采用多因素Logistic回归分析牙列缺失患者种植修复后发生种植体周围黏膜炎的影响因素。绘制受试者工作特征(ROC)曲线分析血清CRP、IL-6对牙列缺失患者种植修复后发生种植体周围黏膜炎的预测价值。结果 随访结果显示,未发生组有89例患者,发生组有31例患者。发生组有吸烟史患者比例及血清CRP、IL-6水平高于未发生组,差异均有统计学意义(P<0.05)。多因素Logistic回归分析结果显示,血清IL-6、CRP水平升高及有吸烟史是牙列缺失患者种植修复后发生种植体周围黏膜炎的危险因素(P<0.05)。ROC曲线分析结果显示,血清IL-6、CRP单独预测牙列缺失患者种植修复后发生种植体周围黏膜炎的曲线下面积(AUC)分别为0.885、0.871,2项指标联合预测的AUC为0.970,大于血清IL-6、CRP单独预测的AUC(Z=2.835、2.375;P=0.005、0.018)。结论 牙列缺失患者种植修复后发生种植体周围黏膜炎时,血清CRP、IL-6水平均升高,二者均为牙列缺失患者种植修复后发生种植体周围黏膜炎的危险因素,且2项指标联合检测对牙列缺失患者种植修复后发生种植体周围黏膜炎的预测效能较高。
Objective To analyze the serum levels of C-reactive protein(CRP)and interleukin-6(IL-6)in edentulous patients and their relationship with peri-implant mucositis after implant restoration.Methods A total of 120 edentulous patients who completed implant restoration treatment Nanjing Stomatological Hospital,Affiliated Hospital of Medical School from January 2022 to June 2023 were selected as the research subjects.The patients were divided into the occurrence group and the non-occurrence group according to the occurrence of peri-implant mucositis after implant restoration.The serum levels of CRP and IL-6 in patients were detected by enzyme-linked immunosorbent assay.Multivariate Logistic regression was used to analyze the influencing factors of peri-implant mucositis after implant restoration in edentulous patients.The receiver operating characteristic(ROC)curve was drawn to analyze the predictive value of serum CRP and IL-6 for peri-implant mucositis in edentulous patients after implant restoration.Results The follow-up results showed that there were 89 patients in non-occurrence group and 31 patients in occurrence group.The proportion of patients with smoking history and serum CRP and IL-6 levels in the occurrence group were higher than those in the non-occurrence group,and the differences were statistically significant(P<0.05).The results of multivariate Logistic regression analysis showed that elevated serum IL-6 and CRP levels and smoking history were risk factors for peri-implant mucositis in edentulous patients after implant restoration(P<0.05).ROC curve analysis showed that the area under the curve(AUC)of serum IL-6 and CRP for predicting peri-implant mucositis after implant restoration in edentulous patients were 0.885 and 0.871 respectively,and the AUC of combined prediction of the two indicators was 0.970.The AUC was greater than that of serum IL-6 or CRP alone(Z=2.835,2.375;P=0.005,0.018).Conclusion The serum levels of CRP and IL-6 are increased in edentulous patients with peri-implant mucositis after implant restoration,which are the risk factors for peri-implant mucositis in edentulous patients after implant restoration.The combined detection of the two indicators has a high predictive efficiency for peri-implant mucositis in edentulous patients after implant restoration.
作者
杨萌
王亚昕
王娟
YANG Meng;WANG Yaxin;WANG Juan(Department of Oral Implantology,Nanjing Stomatological Hospital,Affiliated Hospital of Medical School,Research Institute of Stomatology,Nanjing University,Nanjing,Jiangsu 210008,China;Department of Pharmacy,Jiangsu Civil Administration Rehabilitation Hospital,Nanjing,Jiangsu 210003,China)
出处
《检验医学与临床》
2025年第24期3351-3355,共5页
Laboratory Medicine and Clinic
基金
江苏省省级临床重点项目(YKK18128)。
