摘要
目的针对罹患有血流动力学显著意义的动脉导管未闭之早产儿群体,本研究致力于对其在接受布洛芬药物干预过程中所显现出的治疗结局失败现象,其背后潜藏的各类影响因素,展开系统性的探究与深度的剖析。方法确定研究时间为2022年1月至2024年1月,纳选对象均选取医院明确诊断为有血流动力学意义的动脉导管未闭早产儿,入组对象共计108例,入院以后均采取布洛芬进行治疗,依照患儿治疗后动脉导管是否封闭划分为2组,治疗以后动脉导管未闭的患儿纳入对照组(n=24),动脉导管封闭者纳入观察组(n=84),分析患儿治疗失败的相关影响因素。结果本次研究资料证实,入组研究的108例患儿,治疗失败者共计24例,失败率为22.22%(24/108)。两组患儿胎龄、出生体质量、动脉导管两端压差、宫内窘迫、窒息史、合并感染、呼吸支持、新生儿临床危险指数评分、左心房与主动脉根部内径比、首次治疗日龄经差异性评估,所得结果为P<0.05;出生体质量、新生儿临床危险指数评分、呼吸窘迫综合征、窒息史、动脉导管两端压差、呼吸支持、合并感染属于有血流动力学意义的动脉导管未闭早产儿布洛芬治疗失败的独立影响因素,数值对比结果均为P<0.05。结论有血流动力学意义的动脉导管未闭早产儿在采取布洛芬治疗时治疗失败受多因素影响,导致早产儿呼吸支持以及住院治疗时间延长,了解相关影响因素采取预防性防控措施对于提升治疗效果具有积极意义。
Objective This study aimed to systematically investigate and deeply analyze the underlying influencing factors of treatment failure in premature infants with hemodynamically significant patent ductus arteriosus(PDA)during ibuprofen intervention.Methods The study period was set from January 2022 to January 2024.All participants were prematurely born infants diagnosed with hemodynamically significant PDA in the hospital.A total of 108 cases were enrolled,all of whom received ibuprofen treatment.Based on whether the ductus arteriosus closed after treatment,the infants were divided into two groups:the control group(n=24)with PDA remaining open and the observation group(n=84)with PDA closure.The relevant influencing factors of treatment failure were analyzed.Results The study data confirmed that out of the 108 enrolled infants,24 experienced treatment failure,resulting in a failure rate of 22.22%(24/108).A comparative assessment of gestational age,birth weight,pressure difference across the ductus arteriosus,intrauterine distress,history of asphyxia,concurrent infection,respiratory support,neonatal clinical risk index score,left atrium-to-aortic root diameter ratio,and age at first treatment day revealed statistically significant differences(P<0.05).Birth weight,neonatal clinical risk index score,respiratory distress syndrome,history of asphyxia,pressure difference across the ductus arteriosus,respiratory support,and concurrent infection were identified as independent influencing factors of ibuprofen treatment failure in prematurely born infants with hemodynamically significant PDA,with all comparisons showing statistically significant results(P<0.05).Conclusion Treatment failure in prematurely born infants with hemodynamically significant PDA during ibuprofen therapy is influenced by multiple factors,leading to prolonged respiratory support and hospitalization.Understanding these influencing factors and implementing preventive measures can significantly improve treatment outcomes.
作者
郭挺
傅佳煜
陈永存
GUO Ting;FU Jia-yu;CHEN Yong-cun(Department of Pediatrics,the Second Affiliated Hospital of Fujian Medical University,Quanzhou 362000,Fujian Province,China;Beifeng Hospital of Fengze District,Quanzhou 362000,Fujian Province,China)
出处
《罕少疾病杂志》
2025年第12期129-131,共3页
Journal of Rare and Uncommon Diseases
关键词
血流动力学意义
动脉导管未闭
早产儿
布洛芬
治疗失败
危险因素
Hemodynamic Significance
Patent Ductus Arteriosus
Premature Infants
Ibuprofen
Treatment Failure
Risk Factor
