摘要
目的:探讨早产儿血清25-羟维生素D与支气管肺发育不良的关系。方法:研究选择2022年3月—2025年3月福建省新生儿救护中心莆田分中心收治的胎龄<34周的74例早产儿为研究对象,根据出生后28 d发生支气管肺发育不良(BPD)与否分为非BPD组和BPD组,比较两组患儿一般资料及出生时25-(OH)D和28d 25-(OH)D水平,同时对两组患儿影响因素分析中有差异的因素纳入logistic回归模型进行分析。结果:两组患儿胎龄、出生体质量、性别、分娩方式、妊娠期糖尿病、妊娠期高血压、新生儿窒息、PDA比较,差异无统计学意义(P>0.05);BPD组和非BPD组患儿在Apgar评分、机械通气时间、住院天数、无创呼吸支持、新生儿肺炎、新生儿败血症、出生时25-(OH)D、28d 25-(OH)D比较,差异有统计学意义(P<0.05)。BPD组患儿中轻/中度患儿29例,重度BPD患儿8例,重度BPD组出生时25-(OH)D、28 d 25-(OH)D水平均低于轻/中度BPD组(P<0.05)。多因素logistic回归显示,机械通气时间、住院天数、无创呼吸支持、新生儿肺炎、新生儿败血症、28d 25-(OH)D与患儿BPD发生有显著相关性(P<0.05)。结论:早产儿出生及28 d血清25-羟维生素D与BPD发生及严重程度具有相关性,监测及早期补充维生素D能够改善预后。
Objective:To explore the relationship between serum 25-hydroxyvitamin D in premature infants and bronchopulmonary dysplasia.Method:The study selected 74 premature infants with a gestational age of less than 34 weeks admitted to the Putian Branch of Fujian Provincial Neonatal Rescue Center from March 2022 to March 2025 as the research subjects.They were divided into the non-BPD group and the BPD group according to whether bronchopulmonary dysplasia(BPD)occurred 28 days after birth.The general information of the two groups of children and the levels of 25-(OH)D at birth and 28 days of 25-(OH)D were compared.Meanwhile,the factors with differences in the analysis of influencing factors of the two groups of children were included in the logistic regression model for analysis.Result:There were no statistically significant differences in gestational age,birth weight,gender,mode of delivery,gestational diabetes,gestational hypertension,neonatal asphyxia and PDA between the two groups of children(P>0.05).There were statistically significant differences between the BPD group and the non-BPD group in terms of Apgar score,mechanical ventilation time,length of hospital stay,non-invasive respiratory support,neonatal pneumonia,neonatal sepsis,25-(OH)D at birth,and 25-(OH)D at 28 days(P<0.05).Among the children in the BPD group,there were 29 children with mild/moderate BPD and 8 children with severe BPD.The levels of 25-(OH)D at birth and 28 days of 25-(OH)D in the severe BPD group were lower than those in the mild/moderate BPD group(P<0.05).Multivariate logistic regression showed that mechanical ventilation time,length of hospital stay,non-invasive respiratory support,neonatal pneumonia,neonatal sepsis,and 28-day 25-(OH)D were significantly correlated with the occurrence of BPD in children(P<0.05).Conclusion:Serum 25-hydroxyvitamin D at birth and 28 days in premature infants is correlated with the occurrence and severity of BPD.Monitoring and early supplementation of vitamin D can improve prognosis.
作者
姚碧红
宋进宝
YAO Bihong;SONG Jinbao(Putian First Hospital,Putian 351199,China;不详)
出处
《中外医学研究》
2025年第35期10-13,共4页
CHINESE AND FOREIGN MEDICAL RESEARCH
