摘要
目的:观察布洛芬联合盐酸米诺环素治疗2型糖尿病伴慢性牙周炎患者的效果。方法:选取2022年5月至2024年5月该院收治的100例2型糖尿病伴慢性牙周炎患者进行前瞻性研究,按照随机数字表法将其分为对照组和观察组各50例。对照组给予盐酸米诺环素治疗,观察组在对照组基础上联合布洛芬治疗。比较两组临床疗效,治疗前后牙周健康指标(菌斑指数、牙龈指数、探诊深度)水平,龈沟炎性因子[肿瘤坏死因子-α(TNF-α)、白细胞介素-1β(IL-1β)]水平,以及不良反应发生率。结果:观察组治疗总有效率为96.00%(48/50),高于对照组的70.00%(35/50),差异有统计学意义(P<0.05);治疗后,两组菌斑指数、牙龈指数、探诊深度均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组TNF-α、IL-1β水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:布洛芬联合盐酸米诺环素治疗2型糖尿病伴慢性牙周炎患者可提高临床疗效,改善牙周健康,减轻龈沟炎症反应,效果优于单纯盐酸米诺环素治疗。
Objective:To observe effects of Ibuprofen combined with Minocycline hydrochloride in treatment of type 2 diabetes patients with chronic periodontitis.Methods:A prospective study was conducted on 100 patients with type 2 diabetes and chronic periodontitis admitted to the hospital from May 2022 to May 2024.According to the random number table method,they were divided into control group and observation group,50 cases in each group.The control group was treated with Minocycline hydrochloride,while the observation group was treated with Ibuprofen on the basis of that of the control group.The clinical efficacy,the periodontal health indicators(plaque index,gingival index,probing depth)levels,the gingival sulcus inflammatory factors[tumor necrosis factor-α(TNF-α),interleukin-1β(IL-1β)]levels before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 96.00%(48/50),which was higher than 70.00%(35/50)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the plaque index,gingival index and probing depth of the two groups were lower than those before the treatment,those of the observation group were lower than those of the control group,and the differences were statistically significant(P<0.05).The levels of TNF-αand IL-1βin the two groups were lower than those before the treatment,those of the observation group were lower than those of the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Ibuprofen combined with Minocycline hydrochloride in the treatment of type 2 diabetes with chronic periodontitis can improve the clinical efficacy,improve the periodontal health,and reduce the gingival sulcus inflammatory response.Moreover,it is superior to simple Minocycline hydrochloride treatment.
作者
卢园园
刘燕
LU Yuanyuan;LIU Yan(Department of Pharmacy of Zhide Dental Hospital,Zhengzhou 450000 Henan,China)
出处
《中国民康医学》
2025年第20期71-73,共3页
Medical Journal of Chinese People’s Health
关键词
2型糖尿病
慢性牙周炎
布洛芬
不良反应
米诺环素
炎性因子
Type 2 diabetes
Chronic periodontitis
Ibuprofen
Adverse reaction
Minocycline
Inflammatory factor
