摘要
仔猪由于胃肠道和免疫系统发育不完全,易受各种应激因素影响发生断奶应激综合征,导致腹泻等问题,其主要表型之一是水分吸收障碍。肠道液体的吸收和分泌主要通过肠上皮细胞旁途径和跨细胞途径介导,其中跨细胞途径主要受细胞膜水通道蛋白(AQPs)调控。AQPs是一类广泛存在于机体的跨膜蛋白,负责水分子、小分子溶质(如甘油)、气体和离子的跨膜转运,在细胞稳态中发挥关键作用。AQPs的异常表达会导致肠腔内液体和电解质运输紊乱,从而引发腹泻。此外,AQPs的异常表达还与水肿、癌症等疾病有关。尽管AQPs在腹泻和肠道疾病中的作用及调控机制尚未明确,但已有研究表明,营养调控AQPs可缓解多种胃肠道疾病,具有AQPs靶向疗法的潜力。本文将系统综述AQPs在腹泻及肠道疾病中的作用及其营养调控领域的最新进展,为后抗生素时代通过靶向AQPs防治仔猪腹泻的营养调控措施的开发提供参考。
Due to the incomplete development of the gastrointestinal tract and immune system,piglets are highly susceptible to various stress factors,leading to weaning stress syndrome and problems such as diarrhea.One of the main phenotypes is water absorption disorder.The absorption and secretion of intestinal fluid are mainly mediated by the paracellular and transcellular pathways of intestinal epithelial cells,among which the transcellular pathway is mainly regulated by water channel proteins on the cell membrane.Aquaporins(AQPs)are a family of transmembrane proteins widely present in the body,responsible for the transmembrane transport of water molecules,small solutes,gases and ions,and play a key role in maintaining cellular homeostasis.Abnormal expression of AQPs can disrupt disorders in the transport of fluid and electrolytes in the intestinal lumen,thereby causing diarrhea.In addition,abnormal expression of AQPs is also associated with diseases such as edema and cancer.Although the role and regulatory mechanism of AQPs in diarrhea and intestinal diseases are not yet clear,studies have shown that nutritional regulation of AQPs can alleviate various gastrointestinal diseases and has the potential for AQPs-targeted therapy.This review systematically synthesizes recent advances in the role of AQPs in diarrhea and intestinal diseases,and their nutritional regulation,providing a reference for the development of nutritional regulation measures for preventing piglet diarrhea through targeting AQPs in the post-antibiotic era.
作者
江家媛
宋转
孙铝辉
易丹
JIANG Jiayuan;SONG Zhuan;SUN Lyuhui;YI Dan(Hubei Key Laboratory of Animal Nutrition and Feed Science,Wuhan Polytechnic University,Wuhan 430023,China;College of Animal Science and Technology/College of Animal Medicine,Huazhong Agricultural University,Wuhan 430070,China)
出处
《动物营养学报》
北大核心
2025年第11期7251-7263,共13页
CHINESE JOURNAL OF ANIMAL NUTRITION
基金
国家自然科学基金项目(32072762)
湖北省自然科学基金计划创新群体项目(2023AFA018)。
关键词
仔猪
肠道
水通道蛋白
营养调控
piglets
intestine
aquaporins
nutritional interventions
