摘要
目的系统评价肠道菌群代谢产物氧化三甲胺(TMAO)与心血管疾病(CVD)的关系。方法通过计算机检索PubMed、The Cochrane Library、中国知网、万方数据知识服务平台、维普资讯中文期刊服务平台等数据库,纳入有关TMAO与CVD关联性的文献。对纳入文献进行筛选、资料提取和质量评价后,采用R语言4.4软件进行Meta分析。结果共纳入18篇文献,包含18046例研究对象,其中4985例CVD患者,13061例对照者。Meta分析结果显示,CVD组外周血TMAO水平高于对照组(P<0.05),外周血TMAO水平升高是发生CVD的危险因素(P<0.05)。结论肠道菌群代谢产物TMAO水平升高是发生CVD的危险因素,可为防治CVD提供循证依据。
Objective To systematically evaluate the relation between intestinal flora metabolic products trimethylamine N-oxide(TMAO)and cardiovascular disease(CVD).Methods Literature related to the correlation between TMAO and CVD was enrolled through retrieving databases such as PubMed,The Cochrane Library,China National Knowledge Infrastructure,Wanfang Data Knowledge Service Platform,VIP by computer.After screening enrolled literature,extracting data,and evaluating quality,R language 4.4 software was adopted to perform a Meta-analysis.Results A total of 18 literature was enrolled,including 18046 research subjects,therein there was 4985 CVD patients,and 13061 controlled individuals.The results of Meta-analysis revealed that the CVD group exhibited higher peripheral blood TMAO level compared with the control group(P<0.05);furthermore,the elevated peripheral blood TMAO level was the risk factor for the occurrence of CVD(P<0.05).Conclusion Elevated intestinal flora metabolic products TMAO level is the risk factor for the occurrence of CVD,which can provide an evidence-based basis for CVD control and prevention.
作者
柴粒颖
郭涛
李秋琼
陈文达
罗虹
CHAI Liying;GUO Tao;LI Qiuqiong;CHEN Wenda;LUO Hong(Department of Gastroenterology,General Hospital of the Southern Theater Command of the Chinese People's Liberation Army,Guangzhou 510000,Guangdong,China;Department of Special Operations,General Hospital of the Southern Theater Command of the Chinese People's Liberation Army,Guangzhou 510000,Guangdong,China)
出处
《广西医学》
2025年第10期1482-1490,共9页
Guangxi Medical Journal
基金
广东省医学科学技术研究基金项目(A2023298)
南部战区总医院院内科技计划科研项目(2021NZC021)。
关键词
心血管疾病
氧化三甲胺
肠道菌群代谢产物
危险因素
关联性
META分析
Cardiovascular disease
Trimethylamine N-oxide
Intestinal flora metabolic products
Risk factor
Correlation
Meta-analysis
