摘要
AIDS是由HIV感染引起的慢性传染病。AIDS具有高度传染性及不可治愈性,男男性行为(men who have sex with men,MSM)人群是该病的主要发病人群。肠道微生态对于保持肠道黏膜屏障功能、调节固有免疫、保持肠道平衡具有重要作用,而HIV感染会从多个途径破坏机体肠道微生态。由于性交方式的不同,MSM人群的肠道微生态更易发生破坏,且发生HIV感染的风险更高,这提示对于MSM人群,HIV与肠道微生态的相互影响更为深刻。此外,炎症因子与HIV感染、肠道微生态受损具有密切联系,故HIV感染的MSM人群,肠道更易发生炎症相关的肠道微生态受损。不同抗逆转录病毒治疗(antiviral therapy,ART)方案对HIV感染者的肠道菌群影响差异显著,提示临床在选择治疗方案时应充分考虑药物对肠道微生态的潜在影响。本文综述了MSM人群中HIV感染与肠道微生态的关系,为探索肠道微生态与HIV感染相关疾病治疗提供参考。
Acquired immune deficiency syndrome(AIDS)is a chronic infectious disease caused by infection with the human immunodeficiency virus(HIV).Characterized by high transmissibility and incurability,AIDS predominantly affects men who have sex with men(MSM).The gut microbiota plays a crucial role in maintaining intestinal mucosal barrier function,regulating innate immunity,and preserving intestinal homeostasis.However,HIV infection disrupts the host's gut microbiota through multiple pathways.Given their distinct sexual practices,MSM are more susceptible to gut microbiota dysbiosis and exhibit a higher risk of HIV acquisition,suggesting a more pronounced interplay between HIV and gut microbiota in this population.Furthermore,inflammatory cytokines are intricately linked to both HIV infection and gut microbiota impairment,rendering HIV-infected MSM particularly vulnerable to inflammation-associated gut microbial damage.Different antiretroviral therapy(ART)regimens exert significantly varied impacts on the gut microbiota of people living with HIV(PLWH),highlighting the need to carefully consider the potential effects of medications on gut microbial ecology when selecting clinical treatment strategies.This review synthesizes current knowledge on the relationship between HIV infection and gut microbiota in MSM,aiming to inform future exploration of microbiota-targeted interventions for HIV-associated comorbidities.
作者
张培燕
吴伟波
姚伟明
林元龙
王福祥
Zhang Peiyan;Wu Weibo;Yao Weiming;Lin Yuanlong;Wang Fuxiang(Department of Intensive Infectious Diseases,Shenzhen Third People's Hospital,National Clinical Research Center for Infectious Disease,The Second Affiliated Hospital of Southern University of Science and Technology,Guangdong Shenzhen 518112,China)
出处
《新发传染病电子杂志》
2025年第5期86-90,共5页
Electronic Journal of Emerging Infectious Diseases
基金
广东省高水平临床重点专科(深圳市配套经费)(SZGSP011)
深圳市第三人民医院院内项目(G2022136)
深圳市“医疗卫生三名工程”项目资助(SZSM202311033)。
关键词
男男性行为
人类免疫缺陷病毒
肠道微生态
Men who have sex with men
Human immunodeficiency virus
Gut microbiota
