摘要
肺结核是由结核分枝杆菌(Mycobacterium tuberculosis,Mtb)引起的一种严重危害人类健康的慢性传染病。尽管在结核病防治方面取得了一定进展,但全球范围内其发病率和病死率仍然居高不下。近年来,越来越多的研究表明表观遗传修饰在肺结核发病机制中发挥着重要作用。本文综述了DNA甲基化、组蛋白修饰及非编码RNA调控等表观遗传修饰方式在Mtb感染宿主细胞过程中对宿主免疫应答、Mtb潜伏感染与激活以及耐药性产生等方面的影响,旨在为深入理解肺结核发病机制及开发新的诊断和治疗策略提供理论依据。
Tuberculosis,caused by Mycobacterium tuberculosis,is a chronic infectious disease that seriously endangers human health.Despite certain progress in tuberculosis prevention and control,its incidence and mortality rates remain high worldwide.In recent years,an increasing number of studies have shown that epigenetic modifications play a significant role in the pathogenesis of tuberculosis.This article reviews the effects of epigenetic modifications such as DNA methylation,histone modification,and non-coding RNA regulation on host immune response,latent infection and activation of Mycobacterium tuberculosis,and drug resistance during host cell infection by Mycobacterium tuberculosis,aims to provide a theoretical basis for a deeper understanding of the pathogenesis of tuberculosis and the development of new diagnostic and therapeutic strategies.
作者
黄捷
玉海玲
谢侃
陆伟光
朱庆东
HUANG Jie;YU Hailing;XIE Kan;LU Weiguang;ZHU Qingdong(First Ward of Tuberculosis Department,HIV/AIDS Clinical Treatment Center of Guangxi(Nanning)and The Fourth People’s Hospital of Nanning,Nanning 530023,China)
出处
《传染病信息》
2025年第5期512-516,共5页
Infectious Disease Information
基金
广西重点研发计划(桂科AB24010148)。
关键词
表观遗传修饰
肺结核
发病机制
研究进展
epigenetic modification
tuberculosis
pathogenesis
research progress
