摘要
背景:尽管非编码RNA及铁死亡在骨关节炎发生发展中的作用已被初步确立并成为研究热点,但目前研究仍面临诸多挑战。目的:系统分析并综述非编码RNA在调控骨关节炎铁死亡过程中作用,并汇总相关研究进展。方法:检索中国知网、万方数据库、维普数据库、PubMed数据库建库至2024年12月发表的相关文献,以“骨关节炎,非编码RNA,微小RNA、长链非编码RNA、环状RNA、铁死亡”为中文检索词,以“osteoarthritis,non-coding RNA,microRNA,long non-coding RNA,circular RNA,ferroptosis”为英文检索词进行检索,排除陈旧以及重复的观点,将检索到的文献进行整理,选取86篇文献进行综述。结果与结论:①长链非编码RNA、环状RNA可作为内源性竞争RNA结合微小RNA,从而调控铁死亡相关基因的表达水平,进而影响骨关节炎发生;②铁死亡的发生机制主要涉及铁代谢紊乱、脂质过氧化以及抗氧化系统崩溃,其中脂质过氧化是核心生化特征;③软骨细胞铁死亡的发生可加剧骨关节炎病理进展;④目前非编码RNA通过调控铁死亡影响骨关节炎的研究还处于早期阶段,未来还需大量研究验证其作为生物诊断标志物以及治疗靶点的可行性。
BACKGROUND:Although the role of non-coding RNAs and ferroptosis in the development of osteoarthritis has been initially established and has become a research hotspot,current studies still face many challenges.OBJECTIVE:To systematically analyze and review the role of non-coding RNAs in regulating ferroptosis during osteoarthritis pathogenesis and summarize related research advances.METHODS:Literature searches were performed in CNKI,WanFang,VIP Chinese Journal Database,and PubMed.The search timeline was from database inception to December 2024.Search terms included“osteoarthritis,non-coding RNA,microRNA,long non-coding RNA,circular RNA,ferroptosis”in both Chinese and English.After excluding outdated or redundant publications,86 relevant articles were ultimately selected for review and analysis.RESULTS AND CONCLUSION:(1)Long non-coding RNAs and circular RNAs can act as competitive endogenous RNAs by binding to microRNAs,thereby regulating the expression levels of ferroptosis-related genes and influencing osteoarthritis development.(2)The mechanisms of ferroptosis primarily involve dysregulated iron metabolism,accumulation of lipid peroxidation,and collapse of the antioxidant defense system,with lipid peroxidation accumulation being the core biochemical feature.(3)Ferroptosis in chondrocytes has been shown to exacerbate osteoarthritis pathological progression.(4)Current research on non-coding RNAs influencing osteoarthritis by regulating ferroptosis is still in its early stages.Future studies are needed to extensively validate their feasibility as diagnostic biomarkers and therapeutic targets.
作者
廖兴传
李光第
吴亚滨
刘星余
万佳佳
Liao Xingzhuan;Li Guangdi;Wu Yabin;Liu Xingyu;Wan Jiajia(Guizhou Medical University,Guiyang 550004,Guizhou Province,China;Affiliated Hospital of Guizhou Medical University,Guiyang 550004,Guizhou Province,China;Shanghai Children’s Medical Center,Guizhou Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Guiyang 550004,Guizhou Province,China)
出处
《中国组织工程研究》
北大核心
2026年第18期4713-4725,共13页
Chinese Journal of Tissue Engineering Research
基金
国家自然科学基金地区科学基金项目(82160432),项目负责人:李光第
贵州省科技厅基础研究项目(黔科合基础-ZK[2022]-一般427),项目负责人:李光第
贵州医科大学国家自然科学基金培育项目(20NSP045),项目负责人:李光第。
