摘要
目的通过系统检索并整合分析中医药治疗前列腺癌的临床随机对照试验,对中医药治疗前列腺癌的整体证据分布进行归纳。方法计算机检索中国知网、万方数据库、维普数据库、中国生物医学文献服务系统、Pub Med、EMbase、Cochrane Library、Web of Science等数据库收录的中医药治疗前列腺癌的文献,检索时间为建库至2024年6月,提取并总结相关信息。结果共纳入115篇临床随机对照试验文献,年发文量总体呈上升趋势,但多数研究规模较小,样本量集中为50~<100例;干预疗程多为4~12周;治疗组以中西医治疗为主,口服中药汤剂是最常用的干预措施;观察指标以前列腺特异性抗原、体力状况、生活质量、不良反应等为主,对中医证候评分、病灶大小、疾病进展等指标的关注度较少。结论中医药治疗前列腺癌的优势良好,但多数文献研究质量一般,建议扩大样本量,对观察周期及临床证型等进一步规范,提高研究质量,以验证中医药治疗前列腺癌的独特疗效。
Objective To systematic research and comprehensive analyze the clinical randomized controlled trials on the traditional Chinese medicine(TCM)treatment of prostate cancer,and to summarize the overall evidence distribution of TCM treatment of prostate cancer.Methods A computerized search was conducted in databases including CNKI,Wanfang,VIP,China Biomedical Literature Service System,PubMed,EMbase,Cochrane Library,and Web of Science for literature on the TCM treatment of prostate cancer.The search period was from the establishment of the databases to June 2024.Relevant information was extracted and summarized.Results A total of 115 clinical randomized controlled trials were included,with an overall upward trend in the annual publication volume.However,most studies had a small scale,with a sample size primarily ranging from 50 to<100 cases.The intervention duration mostly ranged from 4 to 12 weeks.The treatment group primarily utilized a combination of TCM and western medicine,with oral decoctions of TCM being the most commonly used intervention.The main observation indicators included prostate-specific antigen,physical condition,quality of life,and adverse reactions,while there was less focus on TCM syndrome scores,lesion sizes,disease progression,and other indicators.Conclusions The advantages of TCM treatment of prostate cancer are promising,but most literature studies have general quality issues.It is recommended to expand the sample size and further standardize the observation period and clinical types to improve research quality,in order to validate the unique efficacy of TCM in treating prostate cancer.
作者
郑青霞
文证
李鸿涵
刘晨光
李其信
傅伟
游旭军
ZHENG Qingxia;WEN Zheng;LI Honghan;LIU Chenguang;LI Qixin;FU Wei;YOU Xujun(Seventh Clinical Medical College,Guangzhou University of Chinese Medicine,Shenzhen 518133,Guangdong,China;Department of Andrology,Bao′an District Traditional Chinese Medicine Hospital,Shenzhen 518133,Guangdong,China)
出处
《中国性科学》
2025年第10期146-151,共6页
Chinese Journal of Human Sexuality
基金
中华中医药学会青年人才托举工程项目(2023-QNRC2-A10)
国家自然科学基金项目(82104853)
中国博士后科学基金面上项目(2024M750265)
广东省自然科学基金项目(2024A1515012209)
广东省中医药局课题项目(20221339)
深圳市宝安区中医院资助项目(BAZYY20220703,BAZYY20200610)。
关键词
前列腺癌
中医药疗法
临床随机对照试验
证据图
Prostate cancer
Traditional Chinese medicine therapy
Clinical randomized controlled trial
Evidence map
