摘要
目的探究胰岛素抵抗型糖尿病患者应用沙格列汀二甲双胍治疗对心血管功能及胰岛功能的影响。方法根据不同的治疗方法将2024年1—9月昆明医科大学第二附属医院医院接受治疗的胰岛素抵抗型糖尿病患者90例分为对照组和研究组。对照组(n=45)应用二甲双胍治疗,研究组(n=45)应用沙格列汀二甲双胍治疗,比较两组临床疗效、血糖水平、胰岛功能、心血管功能。结果治疗6个月后,相比于对照组,研究组空腹血糖、餐后2 h血糖、胰岛素抵抗指数、空腹胰岛素、糖化血红蛋白更低,胰岛β细胞功能指数、Valsalva动作指数、QT离散度、治疗总有效率更高,差异均有统计学意义(P均<0.05)。结论胰岛素抵抗型糖尿病患者应用沙格列汀二甲双胍治疗效果显著,有助于控制血糖水平,改善心血管功能及胰岛功能。
Objective To explore the effects of saxagliptin and metformin treatment on cardiovascular function and islet function in patients with insulin-resistant diabetes.Methods According to different treatment methods,a total of 90 patients with insulin-resistant diabetes who were treated in the Second Affiliated Hospital of Kunming Medical University from January to September 2024 were selected and divided into the control group and the study group.The control group(n=45)was treated with metformin,while the study group(n=45)was treated with saxagliptin metformin.The clinical efficacy,blood glucose level,islet function and cardiovascular function of the two groups were compared.Results After 6 months of treatment,compared with the control group,the fasting plasma glucose,2-hour postprandial plasma glucose,insulin resistance index,fasting insulin and glycated hemoglobin A1c in the study group were lower,and the isletβcell function index,Valsalva action index,QT dispersion and total effective rate of treatment were higher,the differences were statistically significant(all P<0.05).Conclusion The application of saxagliptin metformin in patients with insulin-resistant diabetes has a significant therapeutic effect,which is helpful for controlling blood glucose levels,improving cardiovascular function and islet function.
作者
李毅
柯亭羽
LI Yi;KE Tingyu(Department of Endocrinology,the Second Affiliated Hospital of Kunming Medical University,Kunming 650000,Yunnan,China)
出处
《糖尿病新世界》
2025年第16期76-79,共4页
Diabetes New World
关键词
糖尿病
胰岛素抵抗
沙格列汀二甲双胍
心血管功能
胰岛功能
Diabetes mellitus
Insulin resistance
Saxagliptin metformin
Cardiovascular function
Islet function
