摘要
产后抑郁(postpartum depression,PPD)是产妇在分娩后4~6周内出现的以情绪低落、兴趣减弱、快感缺失为核心症状的抑郁障碍。其危害具有多维性,不仅严重影响母亲的身心健康,还对婴幼儿的行为、情感和认知发展有不利影响,因此受到社会广泛关注。多巴胺(dopamine,DA)作为中枢神经系统中关键的儿茶酚胺类神经递质,通过调节中脑-边缘通路、中脑-皮质通路等多个神经通路,参与调节情绪、动机、奖励机制及运动控制等过程。DA受体已被证实是多种精神类疾病的治疗靶点,且DA奖赏通路敏感性降低会导致快感缺失或动机缺乏,而快感缺失是抑郁症的典型临床症状之一。因此本文将从导致PPD的相关因素、DA系统在PPD中的作用机制、治疗现状等方面展开分析,旨在为将来DA的基础研究及临床干预提供参考。
Postpartum depression(PPD)is a depressive disorder that occurs in women within 4 to 6 weeks after delivery,with core symptoms including low mood,weakened interest and anhedonia.Its harmfulness is multidimensional,not only seriously affects the physical and mental health of mothers,but also has adverse effects on the behavioral,emotional and cognitive development of infants and young children.Therefore,it has received widespread attention from society.Dopamine(DA),as a key catecholamine neurotransmitter in the central nervous system,participates in regulating emotions,motivation,reward mechanisms,and motor control by regulating multiple neural pathways such as the midbrain limbic pathway and midbrain cortex pathway.DA receptors have been confirmed as therapeutic targets for various mental disorders,and reduced sensitivity of the DA reward pathway can lead to anhedonia or lack of motivation,and anhedonia is one of the typical clinical symptoms of depression.Therefore,this article will conduct an analysis from aspects such as the related factors leading to PPD,the mechanism of the DA system in PPD,and the current treatment status,aiming to provide references for the basic research and clinical intervention of DA in the future.
作者
潘丝
何剑波
陈红
PAN Si;HE Jianbo;CHEN Hong(Department of Anesthesiology,the Fifth Affiliated Hospital of Xinjiang Medical University,Urumqi 830011,China;不详)
出处
《中国医学创新》
2025年第30期177-182,共6页
Medical Innovation of China
基金
新疆医科大学第五附属医院青年科研启航项目(XYDWFY-ZR-202416)。
关键词
产后抑郁
多巴胺系统
治疗现状
Postpartum depression
Dopamine system
Treatment status
