摘要
目的探讨产后抑郁患者下丘脑-垂体-肾上腺(HPA)轴激素、甲状腺功能及性激素的水平及其意义。方法选取产后6~7周经我院精神科门诊检测评估为产后抑郁的产妇100例作为抑郁组、100例同期产后未发生抑郁的产妇作为对照组;检测对比两组的HPA激素、甲状腺激素、性激素水平;并分析抑郁组患者各项激素水平与爱丁堡产后抑郁量表(EPDS)评分的关系。结果抑郁组患者的CHR、ACTH水平高于对照组(P<0.05),抑郁组患者的CORT水平低于对照组(P<0.05);抑郁组患者的TSH水平低于对照组(P<0.05),抑郁组患者的TG-Ab、TPO-Ab、FT3、FT4水平与对照组比较,无统计学意义的差异(P>0.05);抑郁组患者的E2水平低于对照组(P<0.05),抑郁组患者的PRL、P值高于对照组(P<0.05);抑郁组患者的E2、TSH、CORT水平与EPDS评分负相关(P<0.05),抑郁组患者的PRL、CHR、ACTH测定值与EPDS评分正相关(P<0.05)。结论产后抑郁患者自身激素水平异于正常产妇,调节产后激素水平可能有利于改善产后抑郁。
Objective To investigate the changes and their significance of thyroid function,hypothalamuspituitary-adrenal(HPA)hormone and sex hormone levels in postpartum depression patients.Methods 100 pregnant women with postpartum depression assessed by our psychiatric outpatient clinic 6 to 7 weeks after delivery were selected as the depression group,and 100 pregnant women who did not experience depression during the same period were selected as the control group,HPA hormones,thyroid function hormones,Sex hormone levels,and analyzed the relationship between the hormone levels of patients in the depression group and the scores of Edinburgh Postpartum Depression Scale(EPDS).Results Compared with patients in the control group,the patients in the depression group had higher levels of CHR and ACTH,lower levels of CORT and TSH(P<0.05).The levels of TG-Ab,TPO-Ab,FT3,and FT4 in patients in the depression group were not significantly different from those in the control group(P>0.05).E2 levels in patients in the depression group were lower than those in the control group(P<0.05).The PRL and P values of the patients were higher than those of the control group(P<0.05).The levels of E2,TSH,and CORT in the depression group were significantly negatively correlated with the EPDS scores(P<0.05).The levels of PRL,CHR,and ACTH of the depression group were significantly positive correlation with EPDS score(P<0.05).Conclusion Postpartum depression patients are significantly changes in their hormone levels.Adjusting the postpartum hormone level shuld be beneficial to alleviate the condition of postpartum depression.
作者
马曙铮
孟宝丽
王宏锋
MA Shuzheng;MENG Baoli;WANG Hongfeng(Department of Gynecology,Pingdingshan Institute of Family Planning,Pingdingshan 467000,China)
出处
《国际精神病学杂志》
2020年第3期504-506,513,共4页
Journal Of International Psychiatry
基金
河南省医学科技攻关计划项目(编号:201602216)。
关键词
产后抑郁
下丘脑-垂体-肾上腺轴
甲状腺功能
性激素
Postpartum depression
Hypothalamic-pituitary-adrenal axis
Thyroid function
Sex hormones
