摘要
生物碱是一类具有化学多样性的含氮次级代谢产物,广泛分布于高等植物、真菌和细菌中。多数天然生物碱具有抗氧化、抗炎、抗肿瘤等生物活性。综述了茶叶中已鉴定的生物碱类群并简要分析其生物活性,包括嘌呤类生物碱通过拮抗腺苷受体调控神经兴奋作用、抑制磷酸二酯酶调控代谢功能及抗炎等生物活性,黄烷类生物碱预防糖尿病、抑制癌细胞血管生成等功效,异戊烯基吲哚类生物碱在抗炎、抑制癌细胞生长、保护神经细胞等方面的作用机制,并对未来茶叶生物碱的鉴定、合成及功能性评价体系构建作了展望。
Alkaloids,as a class of nitrogen-containing secondary metabolites characterized by remarkable chemical diversity,are widely distributed in higher plants,fungi,and bacteria.Most natural alkaloids possess biological activities such as antioxidant,anti-inflammatory,and anti-tumor effects.This review comprehensively summarized the identified alkaloid groups in tea and briefly analyzed their biological activities,including:(1)purine alkaloids,which regulate neural excitability by antagonizing adenosine receptors and inhibiting phosphodiesterase to regulate metabolic functions,exhibit anti-inflammatory,and other biological activities.(2)flavor alkaloids have effects in preventing diabetes and inhibiting cancer cell angiogenesis.(3)the mechanisms by which prenylated indole alkaloids exert anti-inflammatory effects,inhibit cancer cell growth and exert neuro-protective effects.Finally,the future research directions focusing on the identification,appraisal,synthesis and functional evaluation systems of tea alkaloids were proposed.
作者
汤海昆
张兰军
张盼盼
刘本英
TANG Haikun;ZHANG Lanjun;ZHANG Panpan;LIU Benying(Tea Research Institute,Yunnan Academy of Agricultural Sciences,Yunnan Key Laboratory of Tea Science,Kunming 650205,China)
出处
《茶叶科学》
北大核心
2025年第5期727-741,共15页
Journal of Tea Science
基金
创新引导与科技型企业培育计划(202304BI090015)
云南省农业科学院人才引培项目(2024RCYP-01)
云南省科技计划项目基础研究专项(202501CF070035)。
关键词
茶叶
嘌呤生物碱
黄烷生物碱
生物活性
健康功效
tea
purine alkaloids
flavor alkaloids
biological activities
health effects
