摘要
报告浅层X线放射联合外用氟尿嘧啶治疗顽固性皮肤疣2例。患者1,女,13岁,因双手甲周丘疹1年,加重2个月就诊。患者既往使用多种外用药物(维A酸乳膏、咪喹莫特乳膏)及液氮冷冻治疗,效果不佳。皮肤科检查:双手多个甲周可见多个疣状角化丘疹,部分融合、皲裂。诊断:顽固性皮肤疣。患者2,男,16岁,因左足大踇趾丘疹1年,加重3个月就诊。患者既往接受多次液氮冷冻和外用药物(水杨酸贴膏、咪喹莫特乳膏)治疗,疗效不佳。皮肤科检查:左足踇趾可见一枚直径约1 cm黄色疣状角化丘疹,轻度压痛。诊断:顽固性皮肤疣。两例患者均予浅层X线放射(每周1次)联合外用2.5%氟尿嘧啶乳膏封包(每晚1次)治疗。患者1在治疗4周后、患者2在治疗2周后,疣体基本清除,仅遗留暗红斑和色素沉着。随访3个月均无复发。
We report two cases of refractory cutaneous warts successfully treated with a combination of superficial radiotherapy and topical 5-fluorouracil cream.Case 1:a 13-year-old girl presented with a 1-year history of periungual papules on both hands,exacerbated over the past 2 months.The patient had previously used multiple topical medications(tretinoin cream,imiquimod cream)and undergone liquid nitrogen cryotherapy,with poor response.Dermatological examination revealed multiple verrucous,hyperkeratotic papules around the nails of both hands,some of which were confluent and fissured.Diagnosis:Refractory cutaneous warts.Patient 2,a 16-year-old boy presented with a papule on the left big toe for one year,which had worsened over the past three months.The patient had previously undergone multiple sessions of cryotherapy with liquid nitrogen and topical medications(salicylic acid patches,imiquimod cream),but with poor efficacy.Dermatological examination revealed a yellow,verrucous,hyperkeratotic papule approximately 1 cm in diameter on the left big toe,with mild tenderness.Diagnosis:Refractory cutaneous warts.Both patients were treated with superficial X-ray radiotherapy(once weekly)combined with topical 2.5%fluorouracil cream under occlusion once a night.After 4-week treatment,the warts in patient 1 were almost completely resolved,leaving only dark erythema and hyperpigmentation.Patient 2 showed near-complete clearance after a 2-week treatment,with only residual dark erythema and hyperpigmentation.No recurrence was observed in either patient during a 3-month follow-up period.
作者
周政阳
陈旭光
ZHOU Zhengyang;CHEN Xuguang(Dermatology Hospital,Southern Medical University,Guangzhou 510091,China)
出处
《皮肤性病诊疗学杂志》
2025年第9期665-668,共4页
Journal of Diagnosis and Therapy on Dermato-venereology
关键词
顽固性皮肤疣
浅层X线放射
氟尿嘧啶乳膏
recalcitrant cutaneous warts
superficial radiotherapy
fluorouracil cream
