摘要
过敏性鼻炎(AR)是一种由免疫球蛋白E(IgE)介导的Ⅰ型变态反应性疾病,临床表现为鼻黏膜慢性非感染性炎症。AR的发病机制不仅涉及免疫系统,还与神经-内分泌-免疫(NEI)网络失衡密切相关。NEI系统通过共享信息分子,在全身形成复杂的调控网络,共同维持机体内环境稳态。与此同时,十二皮部作为十二经脉功能活动在体表的反应区域,通过营卫之气和络脉系统的协同作用,发挥卫外固表、调和气血的重要功能。皮肤作为NEI系统的重要载体,其组织结构与功能特性与中医学皮部理论存在显著关联。临床观察表明,中医外治法如皮部浅刺、艾灸、推拿、刮痧和经皮给药等通过刺激体表特定部位,能够有效调节营卫功能,改善AR患者的临床症状。然而,目前关于中医外治法治疗AR的具体作用机制仍缺乏系统性的研究证据,特别是对于外治法如何通过皮部调控NEI网络,进而改善AR症状的分子通路尚未完全阐明。因此,从现代医学NEI系统与中医学皮部理论的关联性出发,深入探讨中医外治法治疗AR的潜在作用机制,通过整合中西医理论,不仅有助于揭示传统疗法的科学内涵,也为AR的临床治疗提供新的思路和方法学支持。
Allergic rhinitis(AR)is a type I allergic disorder mediated by immunoglobulin E(IgE),characterized clinically by chronic non-infectious inflammation of the nasal mucosa.The pathogenesis of AR involves not only the immune system but is also closely associated with the imbalance of the neuro-endocrine-immune(NEI)network.The NEI system forms a complex regulatory network throughout the body by sharing information molecules,collectively maintaining homeostasis.Meanwhile,the twelve cutaneous regions represent the surface response areas reflecting the functional activities of the twelve meridians.Through the synergistic actions of nutrient-defense qi and the collateral vessel system,these regions play crucial roles in defending the body′s exterior,consolidating the exterior defense,and harmonizing qi and blood.As an important carrier of the NEI system,the skin exhibits significant correlations between its organizational structure and functional characteristics and the theory of cutaneous regions in traditional Chinese medicine.Clinical observations have demonstrated that the Chinese medicine external treatments,such as superficial needling of the cutaneous regions,moxibustion,tuina massage,scraping therapy,and transdermal drug administration,can effectively regulate nutrient-defense qi function and alleviate clinical symptoms in AR patients by stimulating specific body surface areas.However,there is currently a lack of systematic research evidence regarding the specific mechanisms underlying the treatment of AR with the Chinese medicine external treatment.Especially,the molecular pathways through which external treatments regulate the NEI network through the skin and thereby improve the symptoms of AR have not been fully clarified.Therefore,by exploring the potential mechanisms of the Chinese medicine external treatments for AR from the perspective of the correlation between the modern medical NEI system and the theory of cutaneous regions,and integrating TCM and Western medicine theories,this article not only helps to reveal the scientific connotations of traditional therapies but also provides novel insights and methodological support for the clinical treatment of AR.
作者
李田艺
蒋怀亿
祖芳
任杨慧
杨霖浩
张宁
Li Tianyi;Jiang Huaiyi;Zu Fang;Ren Yanghui;Yang Linhao;Zhang Ning(College of Acupuncture-Moxibustion and Tuina,Guizhou University of Traditional Chinese Medicine,Guiyang Guizhou 550025;The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine,Guiyang Guizhou 550001)
出处
《山西中医药大学学报》
2025年第8期927-933,共7页
Journal of Shanxi University of Chinese Medicine
基金
国家自然科学基金项目(82160937)。
