摘要
失眠是精神心理疾病及多种躯体疾病发生发展的重要危险因素。柴胡疏肝散具有疏肝解郁、行气止痛之功效,在调理情志相关疾病方面疗效显著。在中医理论的深厚根基之上,结合现代药理学研究成果,深入探讨柴胡疏肝散中的单味药、有效成分及其相关药对,综述其通过调节神经递质、抑制细胞凋亡以及降低炎症因子表达等机制,发挥显著的镇静安神功效。期望通过更深入地探究其药用价值,为临床实践应用筑牢理论根基。柴胡疏肝散方中的单味药,如柴胡、白芍、枳壳、川芎、香附、甘草及其有效成分,以及柴胡-白芍等相关药对,都能在一定程度上缓解失眠症状。其作用机制主要聚焦于神经-内分泌-免疫系统,凭借对神经递质的调节、炎症因子的调控以及细胞凋亡的干预,进而发挥出镇静催眠的功效。
Insomnia is an important risk factor for the development of psychiatric and psychological disorders as well as many somatic diseases.Chaihu Shugan Powder(柴胡疏肝散)has the effects of soothing the liver and resolving depression,promoting blood circulation and relieving pain,and has significant therapeutic effects in regulating diseases related to emotions.Based on the profound foundation of traditional Chinese medicine theory and combined with modern pharmacological research results,this article deeply explores the single herbs,effective components and related drug pairs in Chaihu Shugan Powder,which can exert significant sedative and tranquilizing effects through mechanisms such as regulating neurotransmitters,inhibiting cell apoptosis and reducing the expression of inflammatory factors.This article will conduct a comprehensive review of these aspects,hoping to lay a solid theoretical foundation for clinical practice through more in-depth exploration of its medicinal value.The single herbs in this formula,such as Chaihu(Bupleuri Radix),Baishao(Paeoniae Radix Alba),Zhiqiao(Aurantii Fructus),Chuanxiong(Chuanxiong Rhizoma),Xiangfu(Cyperi Rhizoma)and Gancao(Glycyrrhizae Radix et Rhizoma),as well as their effective components and related drug pairs like Bupleuri Radix-Paeoniae Radix Alba,can all alleviate insomnia symptoms to a certain extent.The mechanism of action mainly focuses on the neuro-endocrine-immune system,exerting sedative and hypnotic effects by regulating neurotransmitters,controlling inflammatory factors and intervening in cell apoptosis.
作者
胡文静
王建涛
马惠
王亚男
陈爱霞
胡敏棣
HU Wenjing;WANG Jiantao;MA Hui;WANG Yanan;CHEN Aixia;HU Mindi(Gansu University of Traditional Chinese Medicine,Lanzhou 730030,China;Chengdu University of Traditional Chinese Medicine,Chengdu 610000,China;Gansu Provincinal Hospital of Traditional Chinese Medicine,Lanzhou 730050,China)
出处
《中草药》
北大核心
2025年第15期5690-5698,共9页
Chinese Traditional and Herbal Drugs
基金
甘肃省名中医传承工作室(甘中医药发[2024]7号)。
关键词
柴胡疏肝散
失眠
药对
神经递质
细胞凋亡
炎症因子
柴胡
白芍
枳壳
川芎
香附
甘草
Chaihu Shugan powder
insomnia
medicine pair
neurotransmitter
cell apoptosis
inflammatory factor
Bupleuri Radix
Paeoniae Radix Alba
Aurantii Fructus
Chuanxiong Rhizoma
Cyperi Rhizoma
Glycyrrhizae Radix et Rhizoma
