摘要
目的探讨荣成市胃食管反流病(GERD)的流行病学特征及发病危险因素。方法2023年6—12月前瞻性选择荣成市常住人口4421例为调查对象,通过电话访谈、查阅医疗记录相结合的方式进行GERD流行病学调查。结果本研究共调查了荣成市常住居民4803例,失访率为7.95%(382/4803);GERD患病率为6.11%(270/4421)。与非GERD组比较,GERD组患者年龄较大、体质量指数(BMI)较高、男性比例较高、已婚比例较低(P<0.05)。单因素分析结果表明,胆囊息肉、肠炎、幽门螺杆菌感染、结肠息肉、消化性溃疡、慢性胃炎、冠心病、高血压、糖尿病、咽喉炎、饮酒史、吸烟史、睡眠有问题或烦恼及喜食鱼贝虾类和喜食海藻类食品为GERD的影响因素(P<0.05)。多元Logistic回归分析结果表明,男性、胆囊息肉、肠炎、幽门螺杆菌感染、慢性胃炎、冠心病、高血压、糖尿病、咽喉炎、睡眠有问题或烦恼为GERD的独立危险因素(P<0.05),已婚及喜食鱼、贝、虾类和海藻类海产品为保护性因素(P<0.05)。GERD组健康问卷抑郁量表(PHQ-9)、广泛性焦虑量表(GAD-7)和健康问卷躯体症状群量表(PHQ-15)评分高于非GERD组[8(5,12)分比2(1,4)分、8(5,11)分比2(2,5)分、12(8,16)分比4(2,5)分],差异有统计学意义(P<0.01)。将三项心理状态量表评分分别与GERD量表(GerdQ)评分进行Spearman相关分析,结果发现三项心理状态量表总分与GerdQ总分之间存在正相关关系(r=0.150、0.122、0.153,P<0.05)。结论GERD的病因及发病机制与生活习惯、基础疾病、精神因素等多种因素相关,为降低GERD发病率,应该关注个人生活习惯和饮食习惯的调整,关注心理健康状况。
Objective To explore the epidemiological characteristics and risk factors of gastroesophageal reflux disease(GERD)in Rongcheng city.MethodsFrom June to December 2023,4421 permanent residents of Rongcheng city were selected as the survey subjects,and an epidemiological investigation of GERD was conducted through a combination of telephone interviews and medical records review.ResultsA total of 4803 permanent residents of Rongcheng city were investigated in this study,and the loss of follow-up rate was 7.95%(382/4803).The prevalence rate of GERD was 6.11%(270/4421).Compared with the non-GERD group,patients in the GERD group were older,had a higher body mass index(BMI),had a higher proportion of males,and had a lower proportion of married patients(P<0.05).The results of single factor analysis showed that gallbladder polyp,enteritis,Helicobacter pylori infection,colon polyp,peptic ulcer,chronic gastritis,coronary heart disease,hypertension,diabetes,pharyngitis,drinking history,smoking history,sleep problems or troubles,and eating fish,shellfish,shrimp and seaweed were the influencing factors of GERD(P<0.05).Multiple Logistic regression analysis showed that male,gallbladder polyp,enteritis,Helicobacter pylori infection,chronic gastritis,coronary heart disease,hypertension,diabetes,pharyngitis,and sleep problems or troubles were independent risk factors for GERD(P<0.05),while married and eating fish,shellfish,shrimp and seaweed were protective factors(P<0.05).The scores of Health Questionnaire Depression Scale(PHQ-9),Generalized Anxiety Scale(GAD-7)and Health Questionnaire Somatic Symptom Group Scale(PHQ-15)in the GERD group were higher than those in the non-GERD group:8(5,12)scores vs.2(1,4)scores,8(5,11)scores vs.2(2,5)scores,12(8,16)scores vs.4(2,5)scores,there were statistical differences(P<0.01).The results of Spearman correlation analysis showed that the three mental state scales and GERD scale(GerdQ)scores had positive correlationsrespectively(r=0.150,0.122,0.153,P<0.05).ConclusionsThe etiology and pathogenesis of GERD are related to living habits,basic diseases,mental factors and other factors.In order to reduce the incidence rate of GERD,attention should be paid to the adjustment of personal living habits and eating habits,as well as mental health.
作者
杨晶
玄燕
毛涛
刘福国
Yang Jing;Xuan Yan;Mao Tao;Liu Fuguo(Department of Gastroenterology,the Affiliated Hospital of Qingdao University,Qingdao 266071,China;Department of Psychiatry Outpatient,Rongcheng People's Hospital,Rongcheng 264300,China;Department of Gastroenterology,Rongcheng People′s Hospital,Rongcheng 264300,China)
出处
《中国医师进修杂志》
2025年第10期874-878,共5页
Chinese Journal of Postgraduates of Medicine
基金
山东省中医药科技项目(2021M161)。
