摘要
目的评估呼吸机联合猪肺磷脂注射液应用于新生儿呼吸窘迫综合征(neonatal respiratory distress syndrome,NRDS)中的有效性及不良反应。方法选取2019年1月至2023年1月上饶市妇幼保健院收治的100例NRDS患儿作为研究对象,参照随机数字表法分为对照组与观察组,每组50例。对照组给予呼吸机治疗,观察组在对照组基础上加用猪肺磷脂注射液治疗,比较两组临床疗效、血气指标、肺循环功能、辅助性T细胞(T helper cell,Th)1/Th2平衡、临床指标、不良反应发生情况。结果观察组治疗总有效率为98.00%,高于对照组的86.00%,差异有统计学意义(P<0.05)。治疗后,观察组血氧饱和度、pH、动脉血氧分压均高于对照组,差异有统计学意义(P<0.05)。治疗后,观察组平均肺动脉压、血管外肺水、肺循环阻力均低于对照组,差异有统计学意义(P<0.05)。治疗后,观察组干扰素γ(interferon-γ,IFN-γ)水平、IFN-γ/白细胞介素-4(interleukin-4,IL-4)水平均低于对照组,IL-4水平高于对照组,差异有统计学意义(P<0.05)。观察组无创通气时间、住院时间、呼吸困难改善时间、氧疗时间均短于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较差异无统计学意义。结论呼吸机联合猪肺磷脂注射液治疗NRDS患儿,可提高临床疗效,改善肺循环功能、血气指标,调节Th1/Th2平衡,缩短各项恢复时间,且不良反应少,值得临床推广。
Objective To evaluate the effectiveness and adverse reactions of ventilator combined with porcine pulmonary phospholipid injection in the treatment of neonatal respiratory distress syndrome(NRDS).Methods 100 children with NRDS from January 2019 to January 2023 were selected as the research subjects,and they were divided into the control group and the observation group according to the random number table method,with 50 cases in each group.The control group were treated with ventilator,and the observation group were treated with porcine pulmonary phospholipid injection,and the clinical efficacy,blood gas index,pulmonary circulation function,T helper cell(Th)1/Th2 balance,clinical indexes and adverse reactions were evaluated between the two groups.Results The total effective rate of treatment in the observation group was 98.00%,which was higher than 86.00%in the control group,and the difference was statistically significant(P<0.05).After treatment,the blood oxygen saturation,pH and arterial partial pressure of oxygen in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the average pulmonary artery pressure,extravascular lung water and pulmonary circulation resistance in the observation group were all lower than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the levels of interferonγ(IFN-γ)and IFN-γ/interleukin-4(IL-4)in the observation group were lower than those in the control group,and the level of IL-4 was higher than that in the control group,the differences were statistically significant(P<0.05).The non-invasive ventilation time,hospital stay,improvement time of dyspnea and oxygen therapy time in the observation group were all shorter than those in the control group,and the differences were statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups.Conclusion Ventilator combined with porcine pulmonary phospholipid injection in the treatment of children with NRDS can improve clinical efficacy,improve pulmonary circulation function,blood gas indexes,regulate Th1/Th2 balance,shorten the recovery time,and have fewer adverse reactions,which is worthy of clinical promotion.
作者
许志成
应财涛
陈敏
XU Zhicheng;YING Caitao;CHEN Min(Department of Neonatology,Maternity and Child Healthcare Hospital,Shangrao,Jiangxi,334000,China)
出处
《当代医学》
2025年第8期56-60,共5页
Contemporary Medicine
关键词
呼吸机
猪肺磷脂注射液
新生儿呼吸窘迫综合征
不良反应
Ventilator
Porcine pulmonary phospholipid injection
Neonatal respiratory distress syndrome
Adverse reactions
