摘要
目的探究与分析低分子量肝素钙联合来曲唑促排卵在多囊卵巢综合征(polycystic ovary syndrome,PCOS)治疗中的应用价值。方法选取荆门市掇刀人民医院自2019年3月—2022年6月收治的PCOS不孕症患者120例为研究对象,采取随机数字表法分为对照组与观察组,各60例,2组均给予枸橼酸氯米芬胶囊治疗,对照组加用低分子量肝素钙治疗,观察组在对照组基础上增加来曲唑治疗,对比2组患者治疗后血清性激素水平、免疫调控指标水平,及治疗后随访6个月的排卵与临床妊娠情况。结果治疗后,观察组的睾酮(testosterone,T)、促卵泡激素(follicle-stimulating hormone,FSH)、黄体生成素(luteinizing hormone,LH)、自然杀伤细胞(natural killer cell,NK cell)、干扰素(interferon-γ,INF-γ)、白细胞介素-4(interleukin-4,IL-4)及辅助性T细胞(helper T cell,Th)1/Th2水平分别为(1.36±0.40)mmol/L、(5.16±1.55)U/L、(5.20±1.45)U/L、(6.77±2.36)%、(15.20±6.25)pg/mL、(1.29±0.29)ng/mL、(20.55±17.20),低于对照组的(2.18±0.45)mmol/L、(6.23±1.48)U/L、(9.84±2.33)U/L、(11.98±3.25)%、(18.97±7.33)pg/mL、(1.41±0.21)ng/mL、(27.39±16.78),雌二醇(estradiol,E_(2))水平为(81.58±34.77)pg/mL,高于对照组的(58.10±26.33)pg/mL,差异均有统计学意义(P<0.05)。治疗后随访6个月,观察组的成熟卵泡数为(2.14±0.50)个/个月,多于对照组的(1.48±0.23)个/个月,成熟卵泡平均直径为(24.25±5.22)mm,大于对照组的(19.60±5.34)mm,周期排卵率与临床妊娠率分别为85.00%、51.67%,高于对照组的60.00%、28.33%,差异均有统计学意义(P<0.05)。结果低分子量肝素钙联合来曲唑治疗PCOS不孕症可调节患者的性激素及免疫调控指标水平,促进排卵,从而获得更好的临床妊娠结局。
Objective To explore and analyze the application value of low-molecular-weight heparin calcium combined with letrozole in ovulation induction in for the treatment of polycystic ovary syndrome(PCOS).Methods A total of 120 cases of infertility with PCOS admitted to Jingmen Duodao People's Hospital from March 2019 to June 2022 were selected as the study subjects.They were divided into a control group and an observation group by random number table method,with 60 cases in each group.Both groups received treatment with clomiphene citrate capsules.The control group additionally received low-molecular-weight heparin calcium,while the observation group received letrozole in addition to the control group's treatment.The serum sex hormone levels and immune regulation indexes were compared between the two groups after treatment,and ovulation outcomes and clinical pregnancy status were compared between the two groups during follow-up 6 months after treatment.Results After treatment,the levels of testosterone(T),follicle-stimulating hormone(FSH),luteinizing hormone(LH),natural killer cell(NK cell),interferon-γ(INF-γ),interleukin-4(IL-4),and helper T cell(Th)1/Th2 in the observation group were(1.36±0.40)mmol/L,(5.16±1.55)U/L,(5.20±1.45)U/L,(6.77±2.36)%,(15.20±6.25)pg/mL,(1.29±0.29)ng/mL,and(20.55±17.20),respectively,which were lower than the control group's(2.18±0.45)mmol/L,(6.23±1.48)U/L,(9.84±2.33)U/L,(11.98±3.25)%,(18.97±7.33)pg/mL,(1.41±0.21)ng/mL,and(27.39±16.78),and the level of estradiol(E_(2))was(81.58±34.77)pg/mL,which was higher than the control group's(58.10±26.33)pg/mL,and the differences were statistically significant(P<0.05).During the 6-month follow-up after treatment,the number of mature follicles in the observation group was(2.14±0.50)per month,which was higher than the control group's(1.48±0.23)per month,the average diameter of mature follicles was(24.25±5.22)mm,which was higher than the control group's(19.60±5.34)mm;the ovulation rate and clinical pregnancy rate were 85.00%and 51.67%,respectively,which were higher than those in the control group(60.00%and 28.33%),and the differences were statistically significant(P<0.05).Conclusion Low-molecular-weight heparin calcium combined with letrozole in the treatment of infertility of PCOS can regulate the levels of sex hormones and immune regulation indexes,promote ovulation,and obtain better clinical pregnancy outcomes.
作者
李超
杨春红
LI Chao;YANG Chunhong(Department of Pharmacy,Jingmen Duodao People's Hospital,Jingmen Hubei 448000,China;Department of Gynaecology and Obstetrics,Jingmen Duodao People's Hospital,Jingmen Hubei 448000,China)
出处
《中国卫生标准管理》
2025年第14期119-122,共4页
China Health Standard Management
关键词
来曲唑
低分子量肝素钙
多囊卵巢综合征
不孕症
免疫调控
妊娠率
letrozole
low-molecular-weight heparin calcium
polycystic ovary syndrome
infertility
immune regulation
pregnancy rate
