摘要
目的:探讨左氧氟沙星联合双歧杆菌四联活菌片治疗急性腹泻的效果。方法:选取2021年3月至2024年3月期间本院收治的108例急性腹泻患者,随机分为对照组和观察组(n=54)。对照组口服左氧氟沙星片500 mg,1次·d^(-1);观察组在对照组基础上联合口服双歧杆菌四联活菌片1.5 g,3次·d^(-1),均连续治疗3 d。治疗前及治疗后次日分别采用分光光度法测定二胺氧化酶(Diamine oxidase,DAO)、D-乳酸水平,活检平板计数法测定乳酸菌、双歧杆菌水平,酶联免疫吸附法(Enzyme linked immunosorbent assay,ELISA)测定C反应蛋白(C-reactive protein,CRP)、白细胞介素-6(Interleukin-6,IL-6)、肿瘤坏死细胞因子-α(Tumor necrosis factor-α,TNF-α)水平,并于治疗期间记录腹泻停止时间、腹痛消失时间及不良反应发生例数。结果:治疗后,两组DAO、D-乳酸水平均较治疗前降低,并且观察组DAO、D-乳酸水平均低于对照组(P<0.05)。治疗后,两组的乳酸菌、双歧杆菌含量均较治疗前提高,并且观察组乳酸菌、双歧杆菌含量均高于对照组(P<0.05)。治疗后,两组CRP、IL-6、TNF-α水平均较治疗前降低,且观察组CRP、IL-6、TNF-α水平均低于对照组(P<0.05)。观察组腹泻停止时间、腹痛消失时间均短于对照组(P<0.05)。两组不良反应发生率无显著差异(P>0.05)。结论:左氧氟沙星联合双歧杆菌四联活菌片治疗急性腹泻效果更好,患者恢复更快,且安全性较高。
Objective:To investigate the efficacy of levofloxacin combined with bifidobacterium tetrad in the treatment of acute diarrhea.Methods:A total of 108 patients with acute diarrhea admitted to our hospital from March 2021 to March 2024 were selected.Patients were randomly divided into a control group and an observation group(n=54).The control group took Levofloxacin Tablets 500 mg orally,once daily.The observation group was treated with a combination of oral administration of 1.5 g of Bifidobacterium quadrivalent active bacterial tablets based on the control group,three times daily.Both groups were treated continuously for 3 days.The levels of diamine oxidase(DAO)and D-lactic acid were measured by spectrophotometry before treatment and the next day after treatment.The levels of lactic acid bacteria and bifidobacteria were measured by the biopsy plate counting method.The levels of C-reactive protein(CRP),interleukin-6(IL-6),and tumor necrosis factor-α(TNF-α)were measured by enzyme-linked immunosorbent assay(ELISA).The time of diarrhea stopped,the disappearance time of abdominal pain,and the number of adverse reactions were recorded during the treatment.Results:After treatment,DAO and D-lactic acid levels in both groups were significantly lower than before treatment,and DAO and D-lactic acid levels in the observation group were significantly lower than those in the control group(P<0.05).After treatment,the contents of Lactobacillus and bifidobacterium in both groups were significantly higher than before treatment,and the contents of Lactobacillus and bifidobacterium in the observation group were significantly higher than those in the control group(P<0.05).After treatment,the levels of CRP,IL-6,and TNF-αin both groups were significantly lower than before treatment,and the levels of CRP,IL-6,and TNF-αin the observation group were significantly lower than those in the control group(P<0.05).The diarrhea-stopping time and abdominal pain disappearing time in the observation group were significantly shorter than those in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Levofloxacin combined with bifidobacterium tetrad tablet has better efficacy in treating acute diarrhea,faster recovery for patients,and higher safety.
作者
裴晓庆
Pei Xiao-qing(Department of Pharmacy,Jinshui District General Hospital,Zhengzhou 450000,China)
