摘要
目的探讨左氧氟沙星联合蒙脱石散对细菌性痢疾患者症状、炎症反应的改善效果。方法选取2022年1月—2023年4月收诊的112例细菌性痢疾成人患者作为研究对象,用随机数字表法分为试验组和对照组,每组56例。对照组使用左氧氟沙星片治疗,试验组在对照组治疗的基础上加服蒙脱石散。分别检测2组的血清C反应蛋白(C-reactive protein,CRP)、降钙素原(procalcitonin,PCT)水平、外周血白细胞计数(white blood cell count,WBC)。比较2组患者的各种症状消失时间、治疗1周后的病原菌转阴率、治疗前后的CRP、PCT和WBC水平变化及临床疗效。结果与对照组[(18.34±3.82)h、(15.79±2.84)h、(2.36±0.94)d、(1.41±0.46)d]比较,试验组的呕吐消失时间[(15.56±2.77)h]、发热消失时间[(11.34±2.29)h]、腹痛消失时间[(1.82±0.73)d]和排便次数恢复正常时间[(1.25±0.31)d]均明显缩短,差异有统计学意义(t=4.409、9.128、3.395、2.158,P<0.05)。对照组患者的病原菌转阴率(45/56,80.36%)明显低于试验组(53/56,94.64%),差异具有统计学意义(χ^(2)=21.606,P<0.05)。治疗前,2组的CRP、PCT、WBC水平比较差异均无统计学意义(P>0.05);治疗后,2组的CRP、PCT、WBC水平均低于治疗前(P<0.05),且试验组均低于对照组(P<0.05)。对照组的治疗总有效率(48/56,85.71%)低于试验组(54/56,96.43%),差异无统计学意义(P>0.05)。结论左氧氟沙星联合蒙脱石散能够有效缩短细菌性痢疾患者的症状改善时间,降低PCT等炎症指标水平,临床疗效较好。
Objective To explore the improvement effect of levofloxacin combined with Montmorillonite Powder on symptoms and inflammation in patients with bacillary dysentery.Methods A total of 112 adult patients with bacillary dysentery admitted to our hospital from January 2022 to April 2023 were enrolled and grouped into an experimental group(n=56)and a control group(n=56)according to random number table method.The control group was treated with Levofloxacin Tablets,while the experimental group was treated with Montmorillonite Powder based on the control group regimen.The levels of serum C-reactive protein(CRP),procalcitonin(PCT),and white blood cell count(WBC)in peripheral blood of the 2 groups were detected respectively.The disappearance time of various symptoms,the negative conversion rate of pathogenic bacteria 1 week after treatment,the changes in CRP,PCT and WBC levels before and after treatment,and the clinical efficacy of the 2 groups of patients were compared.Results Compared with the control group[(18.34±3.82)h,(15.79±2.84)h,(2.36±0.94)d,(1.41±0.46)d],the disappearance time for vomiting[(15.56±2.77)h],fever[(11.34±2.29)h],the disapperence of time when abdominal pain[(1.82±0.73)d],and the recovery time[(1.25±0.31)d]of bowel movements frequency in the experimental group were obviously reduced,and the difference was statistically significant(t=4.409,9.128,3.395,2.158,P<0.05).The negative conversion rate of pathogenic bacteria in the control group(45/56,80.36%)was obviously lower than that in the experimental group(53/56,94.64%),the difference was statistically significant(χ^(2)=21.606,P<0.05).Before treatment,there was no statistically significant difference in the levels of CRP,PCT and WBC between the 2 groups(P>0.05).After treatment,the levels of CRP,PCT and WBC in both groups were lower than those before treatment(P<0.05),and those in the experimental group were lower than those in the control group(P<0.05).The total effective rate of the control group(48/56,85.71%)was lower than that of the experimental group(54/56,96.43%),but no statistical difference was observed(P>0.05).Conclusion Levofloxacin combined with Montmorillonite Powder can effectively shorten the improvement time of bacillary dysentery symptoms and reduce the level of inflammatory indicators such as PCT,with high clinical efficacy.
作者
汤文雯
童宁
池云
TANG Wenwen;TONG Ning;CHI Yun(Pharmacy Department of Nanjing Second Hospital,Nanjing 210003,China;Infection Department of Nanjing Second Hospital,Nanjing 210003,China)
出处
《西北药学杂志》
2025年第4期151-155,共5页
Northwest Pharmaceutical Journal
基金
南京市医学科技发展项目(编号:YKK2021056)。
关键词
细菌性痢疾
左氧氟沙星
蒙脱石散
降钙素原
bacterial dysentery
levofloxacin
Montmorillonite Powder
procalcitonin
