摘要
目的分析幽门螺杆菌(Hp)阳性消化性溃疡患儿病原菌根除效果的影响因素。方法选取2023年2月至2024年12月于西安国际医学中心医院就诊的85例Hp阳性消化性溃疡患儿为研究对象进行回顾性分析。所有患儿均予以Hp根除四联疗法,共治疗4周。以Hp根除效果为依据,分为根除组与未根除组。收集患儿的临床资料,对Hp根除效果的影响因素进行多因素分析。结果纳入的85例患儿中,根除成功60例(70.59%),根除失败25例(26.41%)。根除组克拉霉素耐药、阿莫西林耐药、营养不良、有低蛋白血症、有家族胃病史、有先天性疾病、依从性差者占比低于未根除组(P<0.05)。多因素logistic分析显示,克拉霉素耐药、阿莫西林耐药、营养不良、有家族胃病史、依从性差为影响根除效果的危险因素(OR分别为2.022、1.980、1.923、2.022和1.815,P<0.05)。结论Hp阳性消化性溃疡患儿克拉霉素耐药、阿莫西林耐药、营养不良、有家族胃病史、依从性差会影响Hp的根除效果,临床应及时予以针对性干预。
Objective To analyze the influencing factors on the eradication effect of pathogenic bacteria in children with Helicobacter pylori(Hp)positive peptic ulcer.Methods A total of 85 children with Hp positive peptic ulcer in Xi’an International Medical Center Hospital from February 2023 to December 2024 were selected as the research subjects for retrospective analysis.All the children were given the quadruple therapy for Hp eradication for a total of 4 weeks.Based on the eradication effect of Hp,they were divided into the eradication group and the noneradication group.The clinical data of the children were collected,and the multivariate analysis was conducted on the influencing factors of the eradication effect of Hp.Results Among the 85 included children,60 cases(70.59%)were successfully eradicated and 25 cases(26.41%)failed.The proportion of Clarithromycin resistance,Amoxicillin resistance,malnutrition,hypoproteinemia,family history of stomach diseases,congenital diseases,and poor compliance in the eradication group was lower than that in the non-eradication group(P<0.05).Multivariate logistic analysis showed that Clarithromycin resistance,Amoxicillin resistance,malnutrition,family history of stomach diseases,and poor compliance were risk factors affecting the eradication effect(OR were 2.022,1.980,1.923,2.022 and 1.815,respectively,P<0.05).Conclusion Clarithromycin resistance,Amoxicillin resistance,malnutrition,family history of gastric diseases,and poor compliance will affect the eradication effect of Hp in children with Hp positive peptic ulcer,and targeted intervention should be given in time.
作者
马丹阳
姜炜琦
MA Danyang;JIANG Weiqi(College of Traditional Chinese Medicine,Baoji Vocational&Technical College,Shaanxi Province,Baoji 721013,China;Department of No.1 Pediatric Internal Medicine,Xi’an International Medical Center Hospital,Shaanxi Province,Xi’an 710100,China)
出处
《妇儿健康导刊》
2025年第18期44-47,60,共5页
Journal of Women and Children's Health Guide
关键词
幽门螺杆菌
消化性溃疡
病原菌根除效果
影响因素
Helicobacter pylori
Peptic ulcer
Eradication effect of pathogenic bacteria
Influencing factor
