摘要
目的系统评价远端缺血预处理(remote ischaemic preconditioning,RIPC)在选择性血管手术中的临床效果。方法计算机检索The Cochrane Library、PubMed、EMbase、Web of Science、中国知网(CNKI)、万方(Wanfang Data)、维普(VIP)、中国生物医学文献数据库(CBM),根据纳入和排除标准筛选相关随机对照试验。采用RevMan 5.3软件进行Meta分析,采用Cochrane偏倚风险评估工具进行偏倚风险评价。结果共纳入研究15篇,涉及1382例患者。Meta分析结果显示,RIPC与非RIPC在降低选择性血管手术围术期死亡率方面差异无统计学意义(P>0.05)。两组血管手术患者心肌梗死、肾损伤发生率、术后卒中、术后住院时间、手术时间或麻醉总时间、肢体损伤、心律失常、心力衰竭和肺炎发生率等差异无统计学意义(P>0.05)。结论对于接受选择性血管手术患者,RIPC与非RIPC在围术期死亡率和其他临床终点结局方面差异不显著。
Objective To systematically evaluate the clinical effects of remote ischaemic preconditioning(RIPC)in elective vascular surgery.Methods Electronic searches were conducted in The Cochrane Library,PubMed,EMbase,Web of Science,CNKI,Wanfang Data,VIP Database,and CBM.Relevant randomized controlled trials(RCTs)were screened according to inclusion and exclusion criteria.Meta-analysis was performed using RevMan 5.3 software,and the risk of bias was assessed using the Cochrane risk of bias tool.Results A total of 15 studies involving 1382 patients were included.The meta-analysis results showed no statistically significant difference between RIPC and non-RIPC groups in reducing perioperative mortality in elective vascular surgery(P>0.05).There were also no statistically significant differences between the two groups of vascular surgery patients regarding the incidence of myocardial infarction,renal injury,postoperative stroke,postoperative length of hospital stay,duration of surgery or total anesthesia time,or the incidence of limb injury,arrhythmia,heart failure,and pneumonia(P>0.05).Conclusion For patients undergoing elective vascular surgery,there are no significant differences between RIPC and non-RIPC in terms of perioperative mortality and other clinical endpoint outcomes.
作者
刘光祖
刘洪序
卫治理
陈浩
张亚岚
董帅
宋兵
LIU Guangzu;LIU Hongxu;WEI Zhili;CHEN Hao;ZHANG Yalan;DONG Shuai;SONG Bing(The First School of Clinical Medicine,Lanzhou University,Lanzhou,730000,P.R.China;Department of Cardiovascular Surgery,The First Hospital of Lanzhou University,Lanzhou,730000,P.R.China)
出处
《中国胸心血管外科临床杂志》
北大核心
2025年第10期1487-1494,共8页
Chinese Journal of Clinical Thoracic and Cardiovascular Surgery
基金
甘肃省青年科技基金(21JR1RA104)。
关键词
远端缺血预处理
选择性血管手术
临床疗效
系统评价/META分析
Remote ischaemic preconditioning
elective vascular surgery
clinical efficacy
systematic review/meta-analysis
