摘要
目的:探究吉西他滨+顺铂(GP)联合免疫诱导治疗后放疗对局部晚期鼻咽癌患者的影响。方法:回顾性分析2021年1月-2022年12月赣州市肿瘤医院收治的60例局部晚期鼻咽癌患者,根据患者GP化疗后是否联合免疫诱导治疗分为对照组(n=29,GP化疗后行放疗)和观察组(n=31,GP联合免疫诱导治疗后行放疗)。比较两组近期疗效、免疫功能、不良反应发生情况及预后。结果:观察组放疗4周后瘤体缩小情况优于对照组(P<0.05);与治疗前相比,两组治疗后CD4^(+)、CD3^(+)、CD4^(+)/CD8^(+)水平均降低,但与对照组相比,观察组以上指标水平高(P<0.05);两组消化道反应、口腔黏膜炎、白细胞降低、血小板降低发生率比较,差异无统计学意义(P>0.05);观察组皮疹、甲状腺功能减退发生率高于对照组(P<0.05);与对照组相比,观察组远处转移率低(P<0.05);两组死亡率比较,差异无统计学意义(P>0.05)。结论:GP联合免疫诱导治疗后行放疗能够提高局部晚期鼻咽癌患者的临床效果,改善患者免疫功能,降低转移率,但可能增加皮疹、甲状腺功能减退的发生风险。
Objective:To explore the effect of radiotherapy after Gemcitabine+Cisplatin(GP)combined with immune induction therapy on patients with locally advanced nasopharyngeal carcinoma.Method:A retrospective analysis was conducted on 60 patients with locally advanced nasopharyngeal carcinoma admitted to Ganzhou Cancer Hospital from January 2021 to December 2022.They were divided into the control group(n=29,with radiotherapy after GP chemotherapy)and the observation group(n=31,with radiotherapy after GP combined with immune induction therapy)based on whether they received immune induction therapy after GP chemotherapy.The short-term efficacy,immune function,occurrence of adverse reactions and prognosis of the two groups were compared.Result:The tumor volume reduction after 4 weeks of radiotherapy in the observation group was better than that in the control group(P<0.05).Compared with before treatment,the levels of CD4^(+),+CD3^(+) and CD4^(+)/CD8^(+)in the two groups decreased after treatment,but compared with the control group,the levels of the above indicators in the observation group were higher(P<0.05).There were no significant differences in the incidence of digestive tract reaction,oral mucositis,leukopenia,and thrombocytopenia between the two groups(P>0.05).The incidence of rash and hypothyroidism in the observation group were higher than those in the control group(P<0.05).Compared with the control group,the distant metastasis rate in the observation group was lower(P<0.05).There was no significant difference in the mortality rate between the two groups(P>0.05).Conclusion:Radiotherapy after GP combined with immune induction therapy can improve the clinical efficacy of patients with locally advanced nasopharyngeal carcinoma,enhance their immune function,and reduce the metastasis rate,but it may increase the risk of rash and hypothyroidism.
作者
康敏礼
曾汶
叶程远
吴伟
KANG Minli;ZENG Wen;YE Chengyuan;WU Wei(Department of Radiotherapy,Ganzhou Cancer Hospital,Ganzhou 341000,China;不详)
出处
《中国医学创新》
2025年第26期48-51,共4页
Medical Innovation of China
关键词
放疗
特瑞普利单抗
免疫诱导治疗
鼻咽癌
不良反应
预后
Radiotherapy
Toripalimab
Immune induction therapy
Nasopharyngeal carcinoma
Adverse reactions
Prognosis
