摘要
目的探讨血清乳酸脱氢酶(LDH)水平变化对于晚期结直肠癌治疗效果的预测意义。方法回顾性分析福建医科大学附属第一医院化疗科2015年1月~2016年12月有连续治疗的晚期结直肠癌患者在治疗过程中的LDH水平的变化与CEA、疗效评价之间的关系。结果 79例患者中治疗期间出现≥1次PD的52例,52例患者中有42例LDH与疗效评价存在相关性,且差异有统计学意义(P<0.05),其中LDH高于正常者,其LDH与疗效评价的相关性更强,差异有统计学意义(P<0.05);79例患者中,LDH有高于正常的病例其LDH与每次疗效评价相关性显著,而LDH正常病例则仅在第1次疗效评价相关,其他时间点无明确相关,差异无统计学意义(P>0.05);Logistic回归分析发现LDH是影响疗效评价的因素,每次疗效评价与相应的LDH的数值有统计学意义(P>0.05)。结论血清LDH的变化可能可以提示肿瘤治疗期间疗效评价的变化,特别是LDH有高于异常的病例,LDH升高可能可以提示肿瘤进展,LDH降低又有可能提示抗肿瘤治疗有效。
Objective To investigate the predictive value of serum lactate dehydrogenase （LDH） levels in the treatment of advanced coloreetal cancer. Methods the relationship among the advanced LDH levels of patients with rectal cancer during treatment,CEA and the curative effect evaluation were reviewed and analyzed in the First Affiliated Hospital of Fujian Medical University from January 2015 to December 2016. Results There were 52 cases occurred more than 1 PD during the treatment of 79 cases,there were 42 cases of LDH in 52 patients,which were correlated with curative effect evaluation.There was significant difference （P 〈 0.05）.79 patients,LDH was higher than that in normal cases the significant LDH and efficacy evaluation of each correlation,while LDH was only in the first normal cases of curative effect evaluation,the other time points has no clear correlation（P ~ O.05）;Logistic regression analysis was showed that LDH was the influencing factors of curative effect evaluation,numerical time efficacy evaluation and corresponding LDH are statistically significant（P 〈 0.05）. Conclusion The changes of serum LDH may suggest that the tumor during the treatment efficacy evaluation,especially LDH is higher than the abnormal cases,elevated LDH may prompt tumor progression,and decrease of LDH may indicate effective anti tumor therapy.
出处
《中国医药科学》
2017年第20期7-10,15,共5页
China Medicine And Pharmacy
关键词
血清LDH
晚期结直肠癌
疗效评价
化疗
Serum LDH
Advanc, ed colorectal cancer
Efficacy evaluation
Chemotherapy
