摘要
目的探讨早产儿血清维生素A、D水平与坏死性小肠结肠炎(necrotizing enterocolitis,NEC)的相关性。方法采用回顾性研究方法,选取2021年12月至2023年12月在甘肃省妇幼保健院出生的154例早产儿为研究对象,依据是否发生NEC将其分为NEC组(n=77)和对照组(n=77)。比较2组早产儿的一般资料及出生后第1天、第1周、第2周、第1个月的血清维生素A、D水平。统计学方法采用χ^(2)检验或Fisher确切概率法,采用二元Logistic回归分析评价NEC的影响因素。结果NEC组与对照组早产儿的胎龄、出生体质量比较,差异均有统计学意义(P值均<0.05)。NEC组与对照组出生后第1天、第1周及第2周血清维生素A临床缺乏率分别为19.48%与6.49%、19.48%与6.49%、6.49%与0,NEC组均高于对照组,差异均有统计学意义(P值均<0.05)。NEC组与对照组出生后第1天、第1周、第2周及第1个月血清维生素D不足率分别为50.65%与6.49%、44.16%与1.30%、37.66%与1.30%、31.17%与1.30%,NEC组均高于对照组,差异均有统计学意义(P值均<0.001)。二元Logistic回归分析结果显示,NEC的发生与早产儿胎龄、出生体质量、出生后第1天血清维生素A、D水平低有关(P值分别为0.036、0.049、0.006、0.004);血清维生素A、D水平每增加1 nmol/L,发生NEC的风险分别下降0.901倍和0.897倍。结论早产儿血清维生素A、D与NEC的发生相关,且NEC早产儿血清维生素A缺乏及维生素D不足普遍存在。
Objective To investigate the correlation between serum vitamin A and D levels,and necrotizing enterocolitis(NEC)in preterm infants.Method A retrospective study was conducted,selecting 154 preterm infants born at Gansu Provincial Maternal and Child Health Hospital between December 2021 and December 2023 as the study subjects.Based on the occurrence of NEC,they were divided into the NEC group(n=77)and the control group(n=77).The general characteristics of the preterm infants in both groups,as well as their serum vitamin A and D levels on the 1st day,1st week,2nd week,and 1st month after birth were compared.Statistical methods were performed by χ^(2) test or Fisher exact probability method,and binary Logistic regression analysis was used to evaluate influencing factors of NEC.Result Comparisons between the NEC group and the control group of preterm infants showed statistically significant differences in gestational age and birth weight(all P<0.05).The rates of clinical vitamin A deficiency in the NEC group versus the control group on the 1st day,1st week,and 2nd week after birth were 19.48%vs 6.49%,19.48%vs 6.49%,and 6.49%vs 0,respectively.The rates in the NEC group were all higher than those in the control group,with statistically significant differences(all P<0.05).The insufficiency rates of serum vitamin D in the NEC group and the control group on the 1st day,1st week,2 nd week,and 1st month after birth were 50.65%vs 6.49%,44.16%vs 1.30%,37.66%vs 1.30%,and 31.17%vs 1.30%,respectively.The rates in the NEC group were all higher than those in the control group,with statistically significant differences(all P<0.001).Results of binary Logistic regression analysis showed that the occurrence of NEC was associated with low gestational age,low birth weight,and low serum levels of vitamin A and D on the 1st day after birth in preterm infants(P values were 0.036,0.049,0.006,and 0.004,respectively).For each 1 nmol/L increase in serum vitamin A and D levels,the risk of developing NEC decreased by 0.901 and 0.897 times respectively.Conclusion The serum vitamin A and D levels of premature infants are associated with the occurrence of NEC,and vitamin A deficiency and vitamin D insufficiency are commonly present in premature infants with NEC group.
作者
杨早娟
易彬
李建华
周丽
李锦梦
谈笑
李梦洁
刘振亚
Yang Zaojuan;Yi Bin;Li Jianhua;Zhou Li;Li Jinmeng;Tan Xiao;Li Mengjie;Liu Zhenya(Department of Neonatology,Gansu Provincial Maternal and Child Health Hospital/Gansu Provincial Central Hospital,Gansu,Lanzhou 730050,China;Research Center,Gansu Provincial Maternal and Child Health Hospital/Gansu Provincial Central Hospital,Gansu,Lanzhou 730050,China;Department of Digestion and Infection,Gansu Provincial Maternal and Child Health Hospital/Gansu Provincial Central Hospital,Gansu,Lanzhou 730050,China;Department of Neonatology,Xunxian People's Hospital,Henan,Hebi 456250,China;Department of Clinical Laboratory,Gansu Provincial Maternal and Child Health Hospital/Gansu Provincial Central Hospital,Gansu,Lanzhou 730050,China)
出处
《发育医学电子杂志》
2025年第5期338-343,共6页
Journal of Developmental Medicine (Electronic Version)
基金
甘肃省儿科临床医学研究中心项目(18JR2FA004)。
