摘要
鲤鱼在高糖负荷后肝胰脏会产生胰岛素抵抗,已成为限制糖类对于蛋白质节约作用的关键制约因素。关于其产生机制的研究主要集中在胰岛素信号通路等蛋白质编码基因上。目前,针对这一限制因素也已在鲤鱼生长阶段从糖源、糖水平、投喂方式、不同营养物质干预等方面挖掘了一些营养缓解策略。现有的研究缺乏基于细胞层面及表观遗传层面对鲤鱼高糖营养感知机制的认识。亟需进一步阐明鲤鱼糖代谢的生理特点及特殊调控机制,并挖掘出能够缓解鱼类胰岛素抵抗的功能性营养物质或养殖策略。鉴于此,本文从肝胰脏胰岛素抵抗产生机制、营养策略及其缓解肝胰脏胰岛素抵抗的潜在机制和未来研究展望3方面入手,总结该方向的研究进展,丰富对鲤鱼肝胰脏胰岛素抵抗发生调控机制的认识,为提升淀粉等糖类物质的应用,节约鱼粉、豆粕等饲料蛋白质原料奠定坚实理论基础。
The hepatopancreas of common carp(Cyprinus carpio)will produce insulin resistance after high glucose load,which has become a key restriction factor limiting the effect of carbohydrate on protein sparing.Studies on the mechanism of its production mainly focus on protein-coding genes such as insulin signaling pathways.At present,aiming at this limiting factor,some nutrition mitigation strategies have been explored in the aspects of carbohydrate source,carbohydrate level,feeding mode and different nutrient intervention in common carp growth stage.There is a lack of understanding of the mechanism of hyperglycemic nutrient perception in common carp based on cellular level and epigenetic level.It is urgent to further clarify the physiological characteristics and special regulatory mechanisms of glucose metabolism in common carp,and explore functional nutrients or breeding strategies that can alleviate insulin resistance in fish.In view of this,this paper summarized the research progress in this direction from three aspects,the generation mechanism of hepatopancreas insulin resistance,nutritional strategies and their potential mechanisms for alleviating hepatopancreas insulin resistance and the prospect of future research,so as to enrich the understanding of the regulatory mechanism of hepatopancreas insulin resistance in common carp.It lays a solid theoretical foundation for improving starch and other carbohydrate materials application and sparing feed protein raw materials such as fish meal and soybean meal.
作者
范泽
王连生
FAN Ze;WANG Liansheng(Key Laboratory of Aquatic Animal Diseases and Immune Technology of Heilongjiang Province,Heilongjiang River Fisheries Research Institute,Chinese Academy of Fishery Sciences,Harbin 150070,China)
出处
《动物营养学报》
北大核心
2025年第9期5693-5703,共11页
CHINESE JOURNAL OF ANIMAL NUTRITION
基金
中央级公益性科研院所基本科研业务费专项(HSY202408Q)
国家自然基金青年科学基金项目(32302969)
黑龙江省重点研发计划(2024ZX10B06)
中国水产科学研究院中央级公益性科研院所基本科研业务费专项资金(2023TD60)。
关键词
鲤鱼
胰岛素抵抗
产生机制
营养策略
缓解机制
细胞图谱
表观遗传学
common carp
insulin resistance
generation mechanism
nutritional strategies
mitigation mechanism
cell atlas
epigenomics
