摘要
目的基于R语言挖掘探析国家专利中药复方外敷治疗干眼的用药规律。方法纳入2004年1月16日—2023年12月18日中国专利公布公告网站中外敷治疗干眼的中药复方专利。采用Excel软件对中药复方建立数据库并进行数据处理,运用R语言进行频数统计、功效归类、性味归经、关联规则及因子分析。结果(1)一般情况:共纳入专利176项,共涉及中药530味,药物累计频次1,888次,使用频次>10次的中药(高频中药)共有40味。(2)高频中药使用频次:排名前5位的高频中药依次为菊花(80次,45.45%)、枸杞子(55次,31.25%)、决明子(51次,28.98%)、薄荷(49次,27.84%)、麦冬(39次,22.16%)。(3)高频中药功效分类:使用最多为补虚药(13味,32.50%),其次为清热药(12味,30.00%)、解表药(7味,17.50%)等。(4)高频中药性味归经:四气以寒性药最多(21味,52.50%),五味以甘味药最多(26味,40.63%),归经为肝经最多(26味,26.53%)。(5)关联规则分析:排名前5位的高频药对为枸杞子-菊花(40次,31.25%)、决明子-菊花(35次,28.98%)、薄荷-菊花(29次,27.84%)、冰片-薄荷(22次,22.16%)、麦冬-枸杞子(22次,22.16%)。(6)因子分析:共提取6个公因子,涵盖了多种中药,显示了外敷中药治疗干眼的复杂性和多样性。结论外敷治疗干眼遵循润燥生津、清热明目以治其标,补益虚损、滋阴补肾、调和脏腑治其本等治疗原则,为临床用药提供参考。
OBJECTIVE To analyze medication patterns of Chinese herbal formulas for external application in dry eye treatment using patent data and R language.METHODS Chinese patent applications for external herbal treatments of dry eye published between January 16th,2004,and December 18 th,2023,were retrieved from the China Patent Publication Database.Excel was used to establish a database of herbal formulas,and R language was employed for frequency analysis,efficacy categorization,property/channel classification,association rule mining,and factor analysis.RESULTS(1)General data:176 patents involving 530 herbs with 1,888 cumulative frequencies were included;40 high-frequency Chinese Medicines(>10 uses)were identified.(2)High-frequency Chinese medicines:Chrysanthemum morifolium were the most(80 times,45.45%),followed by Lycium barbarum(55 times,31.25%),Senna obtusifolia(51 times,28.98%),Mentha suaveolens(49 times,27.84%),and Ophiopogon japonicus(39 times,22.16%).(3)Efficacy classification:Tonifying Chinese medicines(13 times,32.50%)were most common,followed by heat-clearing Chinese medicines(12 times,30.00%)and exterior-releasing Chinese Medicines(7 times,17.50%).(4)Properties,flavors,and meridian tropism of high-frequency herbs:Among properties,Cold-natured Chinese Medicines were the most(21 times,52.50%),sweet flavor was most frequent(26 times,40.63%),Liver meridian affinity ranked highest(26 times,26.53%).(5)Association rules:Top five herb pairs were Lycium barbarum-Chrysanthemum morifolium(40 times,31.25%),Senna obtusifolia-Chrysanthemum morifolium(35 times,28.98%),Mentha suaveolens-Chrysanthemum morifolium(29 times,27.84%),Borneolum syntheticum-Mentha suaveolens(22 times,22.16%),and Ophiopogon japonicus-Lycium barbarum(22 times,22.16%).(6)Factor analysis:Six common factors revealed treatment complexity and diversity.CONCLUSIONS External treatments follow principles of moisturizing,clearing heat,improving vision,and nourishing deficiencies,regulating organs,providing clinical references.
作者
邸湘雯
胡晓阳
DI Xiangwen;HU Xiaoyang(Heilongjiang University of Chinese Medicine,Harbin 150040,China)
出处
《中国中医眼科杂志》
2025年第10期933-938,967,共7页
China Journal of Chinese Ophthalmology
基金
李冀全国名老中医药专家传承工作室(国中医人发〔2014〕20号)
中医药传承与创新“百千万”人才工程(岐黄工程)岐黄学者项目(国中医药人教函〔2018〕284号)
黑龙江省2023年青年岐黄学者培养项目。
关键词
外敷治疗
干眼
R语言挖掘
用药规律分析
国家专利
external treatment
dry eye
R language mining
medication pattern analysis
national patent
