摘要
目的:通过数据挖掘分析名中医章勤围体外受精-胚胎移植技术(IVF-ET)调治的用药规律。方法:收集整理2021年1月—2024年1月章勤教授门诊诊治的围IVF-ET患者的处方,应用Microsoft Office Excel软件建立数据库,运用中医传承辅助平台V2.5“统计报表”模块的“医案统计”进行证候统计、药物频次统计及性味归经统计,通过“数据分析”模块的“方剂分析”进行组方规律统计及新方分析,并实现网络可视化。结果:共纳入226首处方,包括术前98首,降调期16首,超促排卵期22首,移植前期39首,移植后期51首。涉及148味中药。术前及移植前期证候以肾虚血瘀证为主,降调期以心肾阴虚证为主,超促排卵期以肝肾亏虚证为主,移植后期以脾肾两虚证为主。术前按出现的频次从高到低排序,药物频次≥32次的中药有16味,排在前8位的分别是当归、炒白芍、菟丝子、山药、陈皮、肉苁蓉、川芎、淫羊藿。降调期药物频次≥10次的中药有10味。超促排卵期药物频次≥12次的中药有12味。移植前期药物频次≥20次的中药有11味。移植后期药物频次≥34次的中药有14味。经聚类分析获得新处方,术前及移植后各8首。结论:章勤教授治疗围IVF-ET术前以补肾化瘀药为主,兼用健脾理气药;术中分期论治施药,移植后以健脾补肾、益气安胎药为主。
Objective:To analyze the medication rules of renowned Chinese medicine practioner ZHANG Qin in the treatment of peri-in vitro fertilization-embryo transfer(IVF-ET)technology through data mining.Methods:Formulas for patients with peri-IVF-ET treated by Professor ZHANG Qin in outpatient clinics from January 2021 to January 2024 were collected and sorted.A database was established using Microsoft Office Excel.The"Medical Case Statistics"in the"Statistical Report"module of Traditional Chinese Medicine Inheritance Support System V2.5 was used for syndrome statistics,medicinal frequency statistics,natures,flavors,and channel entries statistics.The"Formula Analysis"in the"Data Analysis"module was applied for statistical analysis of formula composition rules and new formula analysis,with network visualization realized.Results:A total of 226 formulas were included,including 98 before surgery,16 in the down-regulation period,22 in the superovulation period,39 in the pre-transplantation period,and 51 in the post-transplantation period,involving 148 kinds of Chinese herbal medicines.Syndromes before surgery and in the pre-transplantation period were mainly kidney deficiency and blood stasis;those in the down-regulation period were mainly heart-kidney yin deficiency;those in the superovulation period were mainly liver-kidney deficiency;and those in the post-transplantation period were mainly spleen-kidney deficiency.Before surgery,16 Chinese herbal medicines had a frequency≥32 times,with the top eight being Angelicae Sinensis Radix,fried Paeoniae Radix Alba,Cuscutae Semen,Dioscoreae Rhizoma,Citri Reticulatae Pericarpium,Cistanches Herba,Chuanxiong Rhizoma,and Epimedii Folium.Inthedown-regulationperiod,10 Chineseherbal medicines hadafrequency≥10times;inthesuperovulation period,12 had a frequency≥12 times;in the pre-transplantation period,11 had a frequency≥20 times;and in the post-transplantation period,14 had a frequency≥34 times.Cluster analysis obtained new prescriptions,eight for pre-surgery and eight for post-transplantation respectively.Conclusion:Professor ZHANG Qin mainly uses kidney-tonifying and stasis-removing medicines before peri-IVF-ET treatment,combined with spleen-strengthening and qi-regulating medicines;during the procedure,treatment is administered by stages,and after transplantation,spleen-strengthening and kidney-supplementing medicines,and qi-boosting and fetus-stabilizing medicines are mainly used.
作者
何易
章勤(指导)
HE Yi;ZHANG Qin(Hangzhou TCM Hospital of Zhejiang Chinese Medical University,Hangzhou Zhejiang 310007,China)
出处
《新中医》
2025年第18期6-11,共6页
New Chinese Medicine
基金
浙江省中医药科技计划项目(2023ZF029)。
关键词
围体外受精-胚胎移植技术
数据挖掘
中医传承辅助平台
用药规律
章勤
Peri-in vitro fertilization-embryo transfer technology
Data mining
Traditional Chinese Medicine Inheritance Support System
Medication rules
ZHANG Qin
