摘要
目的探讨系统免疫炎症指数(SII)、白蛋白与球蛋白比值(AGR)、超敏C反应蛋白(hs-CRP)在溃疡性结肠炎(UC)合并EB病毒(EBV)感染患者中的水平,评估其对UC合并EBV感染的诊断价值。方法选取2024年2月至2024年9月该院收治的237例UC患者,根据患者EBV-DNA检测结果分为合并组(150例)及对照组(87例),同时收集患者血常规中性粒细胞、淋巴细胞、血小板计数及白蛋白(ALB)、球蛋白、hs-CRP、红细胞沉降率(ESR)等相关指标,并计算SII、AGR等参数。采用Spearman相关性检验行相关性分析。采用多因素二元Logistic回归分析UC患者合并EBV感染的影响因素,采用受试者工作特征(ROC)曲线评估各项指标单独及联合检测的诊断价值。结果合并组和对照组疾病活动度、病变范围、ALB、AGR、ESR、hs-CRP、SII比较,差异均有统计学意义(P<0.05)。合并组EBV-DNA阳性拷贝数与疾病活动度、hs-CRP、SII呈正相关(P<0.05),与ALB、AGR呈负相关(P<0.05)。多因素二元Logistic回归分析结果显示,SII和AGR是UC患者合并EBV感染的独立影响因素(P<0.05)。ALB、AGR、SII、hs-CRP、ESR及各项指标联合检测对UC患者合并EBV感染均具有一定的预测价值。ALB、AGR、SII、hs-CRP、ESR五者联合检测和SII、AGR、hs-CRP三者联合检测的曲线下面积最大,灵敏度和特异度也较高。结论SII和AGR是UC患者合并EBV感染的独立影响因素,SII、AGR、hs-CRP三者联合检测对于UC合并EBV感染具有良好的诊断价值,可作为评估UC合并EBV感染的有价值的标志物。
Objective To investigate the systemic immune-inflammation index(SII),albumin to globulin ratio(AGR),and high-sensitivity C-reactive protein(hs-CRP)in patients with ulcerative colitis(UC)complicated by Epstein-Barr virus(EBV)infection,and to evaluate their diagnostic value in UC complicated by EBV infection.Methods A total of 237 patients with UC admitted to the hospital from February 2024 to September 2024.Patients were divided into a complicated group(150 cases)and a control group(87 cases)based on EBV-DNA test results.The counts of neutrophils,lymphocytes,and platelets,as well as the levels of albumin(ALB),globulin,hs-CRP,and erythrocyte sedimentation rate(ESR)were collected from the patients′routine blood tests,and the parameters of SII and AGR were calculated.Spearman correlation test was used for correlation analysis.Multivariate binary Logistic regression was used to analyze the influencing factors of EBV infection in UC patients,and receiver operating characteristic(ROC)curve was used to evaluate the diagnostic value of individual and combined detection of various indicators.Results There were statistically significant differences in disease activity,lesion range,ALB,AGR,ESR,hs-CRP,and SII between the complicated group and the control group(P<0.05).Correlation analysis showed that the positive copy number of EBV-DNA in the complicated group was positively correlated with disease activity,hs-CRP,and SII(P<0.05),and negatively correlated with ALB and AGR(P<0.05).Multivariate binary Logistic regression analysis indicated that SII and AGR were independent influencing factors for UC patients complicated by EBV infection.The combined detection of ALB,AGR,SII,hs CRP,ESR and various indicators has certain predictive value for UC patients with EBV infection.The area under the curve of the combined detection of ALB,AGR,SII,hs-CRP,ESR and the AUC of the combined detection of SII,AGR,hs-CRP were the largest,and the sensitivity and specificity were also high.Conclusion SII and AGR are independent influencing factors for UC patients complicated by EBV infection.The combined detection of SII,AGR,and hs-CRP has good diagnostic value for UC complicated by EBV infection and could serve as valuable biomarkers for evaluating UC complicated by EBV infection.
作者
陈健康
刘家云
CHEN Jiankang;LIU Jiayun(Deparment of Clinical Laboratory,the First Affiliated Hospital of Air Force Military Medical University,Xi′an,Shaanxi 710032,China)
出处
《国际检验医学杂志》
2025年第17期2092-2096,共5页
International Journal of Laboratory Medicine
基金
国家重点研发计划课题(2022YFC2603705)
陕西省重点研发计划项目(2021ZDLSF06-06)。
关键词
溃疡性结肠炎
EB病毒感染
系统免疫炎症指数
白蛋白与球蛋白比值
超敏C反应蛋白
红细胞沉降率
ulcerative colitis
Epstein-Barr virus infection
systemic immune-inflammation index
albumin to globulin ratio
high-sensitivity C-reactive protein
erythrocyte sedimentation rate
