摘要
目的探讨卡普里尼风险评估模型(Caprini risk assessment model,Caprini)评分在老年尿毒症合并糖尿病患者静脉血栓栓塞风险评估中的临床价值。方法回顾性分析2023年2月—2024年2月莆田学院附属医院收治的80例老年尿毒症患者临床资料,根据是否合并糖尿病,将患者分为合并糖尿病组(n=40)和未合并糖尿病组(n=40)。比较2组凝血功能指标[凝血酶原时间(prothrombin time,PT)、凝血酶时间(thrombin time,TT)、活化部分凝血活酶时间(activated partial thromboplastin time,APTT)和纤维蛋白原(fibrinogen,Fib)]及D-二聚体水平。同时,分析Caprini评分与老年尿毒症合并糖尿病患者凝血功能指标及D-二聚体水平的相关性,进而评估Caprini评分诊断该类患者静脉血栓栓塞的效能。结果合并糖尿病组患者的Fib水平为(6.51±1.32)g/L,高于未合并糖尿病组的(4.12±0.72)g/L,合并糖尿病组患者的D-二聚体水平为(3.21±0.51)g/L,高于未合并糖尿病组的(1.42±0.11)g/L,差异有统计学意义(P<0.001)。此外,Caprini评分与合并糖尿病组患者的Fib水平和D-二聚体水平均呈正相关(P<0.05)。Caprini评分诊断合并糖尿病组患者静脉血栓栓塞的灵敏度为70.8%,特异度为69.8%,约登指数为0.406,曲线下面积(area under the curve,AUC)为0.6568(P=0.008)。结论Caprini评分在评估老年尿毒症合并糖尿病患者静脉血栓栓塞风险方面表现出较好的灵敏度和特异度,提示其具有重要的临床指导意义。
Objective To explore the clinical value of the Caprini risk assessment model(Caprini)score in the risk assessment of venous thromboembolism in elderly uremic patients complicated with diabetes mellitus.Methods Retrospective analysis of clinical data from 80 elderly uremia patients admitted to the Affiliated Hospital of Putian University from February 2023 to February 2024.Patients were divided into a diabetes mellitus group(n=40)and a non-diabetes mellitus group(n=40)based on whether they had diabetes mellitus.Coagulation function indicators[prothrombin time(PT),thrombin time(TT),activated partial thromboplastin time(APTT),and fibrinogen(Fib)]and D-dimer levels were compared between the two groups.Simultaneously,the correlation between the Caprini score and coagulation function indicators and D-dimer levels in elderly uremia patients with diabetes mellitus was analyzed.Subsequently,the diagnostic efficacy of the Caprini score for venous thromboembolism in these patients was evaluated.Results In the diabetes mellitus group,the Fib level was(6.51±1.32)g/L,which was higher than(4.12±0.72)g/L in the non-diabetes mellitus group.The D-dimer level in the diabetes mellitus group was(3.21±0.51)g/L,which was higher than(1.42±0.11)g/L in the non-diabetes mellitus group.The differences were statistically significant(P<0.001).Additionally,the Caprini score was positively correlated with Fib and D-dimer levels in patients of the diabetes mellitus group(P<0.05).The sensitivity of the Caprini score in diagnosing venous thromboembolism in elderly uremia patients with diabetes mellitus was 70.8%,specificity was 69.8%,Youden index was 0.406,and the area under the curve(AUC)was 0.6568(P=0.008).Conclusion The Caprini score showed good sensitivity and specificity in evaluating the risk of venous thromboembolism in elderly uremic patients with diabetes mellitus,suggesting its important clinical guiding significance.
作者
黄明焕
陈洪
许永成
林梅芳
林丹华
HUANG Minghuan;CHEN Hong;XU Yongcheng;LIN Meifang;LIN Danhua(Department of Blood Purification Room,Affiliated Hospital of Putian University,Putian Fujian 351100,China)
出处
《中国卫生标准管理》
2025年第13期111-114,共4页
China Health Standard Management
基金
莆田学院2022年校级科研项目(2022087)。
