摘要
目的通过双向孟德尔随机化分析探究寻常痤疮与91个循环炎症蛋白的因果关系。方法从GWAS数据库获取91个循环炎症蛋白与寻常痤疮的公开数据集,以随机效应逆方差加权法(inverse variance weighted,IVW)、MR-Egger回归、加权中位数法(weight median,WM)、简单模式(simple mode)、加权众数法(weighted mode)5种模型对其因果关系进行双向孟德尔随机化分析。结果91个循环炎症蛋白作为暴露时,白细胞介素-10受体亚基(interleukin-10 receptor subunit beta,IL-10RⅡ)水平(OR=1.42,95 CI:1.16~1.74,P=0.001)与寻常痤疮存在正相关的因果关系,而白血病抑制因子受体(leukemia inhibitory factor receptor,LIFR)水平(OR=0.69,95 CI:0.51~0.94,P=0.020)与寻常痤疮之间存在负相关的因果关系;当以寻常痤疮作为暴露时,提示寻常痤疮与胱抑素D(Cystatin D)(OR=0.97,95 CI:0.95~1.00,P=0.041)、肿瘤坏死因子配体超家族成员14(tumor necrosis factor ligand superfamily member 14,TNFSF14)水平(OR=1.03,95 CI:1.00~1.06,P=0.044)之间存在因果关系。结论IL-10RⅡ水平升高可增加寻常痤疮的发病风险,LIFR水平升高可降低其发病风险;而Cystatin D、TNFSF14水平可作为寻常痤疮的严重程度评判指标。
Objective To investigate the causal relationship between acne vulgaris and 91 circulating inflammatory proteins by bi-directional Mendelian randomisation study.Methods Publicly available datasets for 91 circulating inflammatory proteins and acne vulgaris were obtained from GWAS databases.A bidirectional Mendelian randomization(MR)analysis was performed to assess causal relationships using five models:inverse variance weighted(IVW)with random effects,MR-Egger regression,weighted median(WM),simple mode,and weighted mode.Results Analysis considering the 91 circulating inflammatory proteins as exposures revealed a positive causal link between acne vulgaris and interleukin-10 receptor subunit beta(IL-10RⅡ)levels(OR=1.42,95 CI:1.16-1.74,P=0.001),and a negative association between acne vulgaris and leukemia inhibitory factor receptor(LIFR)levels(OR=0.69,95 CI:0.51-0.94,P=0.020).Conversely,when acne vulgaris was treated as the exposure,a related causal relationship emerged between acne vulgaris and Cystatin D(OR=0.97,95 CI:0.95-1.00,P=0.041),as well as tumor necrosis factor ligand superfamily member 14(TNFSF14)levels(OR=1.03,95 CI:1.00-1.06,P=0.044).Conclusion Elevated IL-10RⅡ levels potentially heighten the risk of acne vulgaris,while the increased level of LIFR can reduce the risk of developing acne vulgaris.Cystatin D and TNFSF14 levels may serve as valuable indicators for assessing acne vulgaris severity.
作者
王志敏
黄文
闫志颖
乔博亚
叶建州
杨雪松
WANG Zhimin;HUANG Wen;YAN Zhiying;QIAO Boya;YE Jianzhou;YANG Xuesong(First School of Clinic Medicine,Yunnan University of Traditional Chinese Medicine,Kunming 650500,China;Department of Dermatology,First Affiliated Hospital of Yunnan Traditional Chinese Medicine University,Kunming 650021,China)
出处
《中国皮肤性病学杂志》
北大核心
2025年第8期838-846,共9页
The Chinese Journal of Dermatovenereology
基金
国家自然科学基金项目(82260940)
云南省中医(皮肤)临床中心
云南省科技厅科技计划项目(202101AZ070001-079)
云南省中医临床优秀人才研修项目。
关键词
寻常痤疮
炎症
白细胞介素-10受体亚基
白血病抑制因子受体
胱抑素D
肿瘤坏死因子配体超家族成员14
Acne vulgaris
Inflammation
Interleukin-10 receptor subunit beta(IL-10RⅡ)
Leukemia inhibitory factor receptor(LIFR)
Cystatin D
Tumor necrosis factor ligand superfamily member 14(TNFSF14)
