摘要
目的 探讨六字诀联合中医外治法对慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)稳定期患者的疗效及炎症因子的影响。方法 选取2021年7月至2023年12月于浙江中医药大学附属第三医院就诊的96例COPD稳定期肺脾气虚证患者随机均分为两组,对照组患者给予西医常规治疗,治疗组患者在西医常规治疗的基础上给予六字诀联合中医外治法治疗,治疗持续8周。观察治疗前后两组患者的中医证候积分、COPD患者生存状况评估指数(body mass index,air flow obstruction,dyspnea and exercise capacity index,BODE指数)及单核细胞趋化蛋白-1(monocyte chemoattractant protein-1,MCP-1)、白细胞介素(interleukin,IL)-35和IL-17含量变化。结果 与治疗前比较,两组患者的中医证候积分、BODE指数、MCP-1及IL-17水平均明显降低,IL-35水平明显升高,差异有统计学意义(P<0.05)。治疗后,治疗组患者的BODE指数、中医证候积分、MCP-1及IL-17水平较对照组更低,IL-35水平较对照组更高,差异均有统计学意义(P<0.05)。结论 六字诀联合中医外治法治疗可改善COPD稳定期患者的BODE指数、中医证候积分,并降低促炎因子MCP-1及IL-17水平,提高抗炎因子IL-35水平。
Objective To investigate the clinical efficacy of the Liuzijue combined with external treatment of traditional Chinese medicine on patients in stable chronic obstructive pulmonary disease(COPD)and its effects on inflammatory factors.Methods A total of 96 patients with COPD in the stable phase presenting with lung and spleen Qi deficiency syndrome were enrolled from the Third Affiliated Hospital of Zhejiang Chinese Medical University from July 2021 to December 2023.The patients were randomly divided into two groups with equal numbers.Control group received conventional Western medical treatment,while treatment group was administered the Liuzijue exercise combined with external treatment of traditional Chinese medicine in addition to conventional Western medical treatment.The intervention lasted for 8 weeks.Changes in traditional Chinese medicine syndrome scores,body mass index,air flow obstruction,dyspnea and exercise capacity(BODE)index,as well as serum levels of monocyte chemoattractant protein-1(MCP-1),interleukin(IL)-35,and IL-17 were observed before and after treatment in both groups.Results Compared with pre-treatment levels,both groups exhibited significant reductions in traditional Chinese medicine syndrome scores,BODE index,MCP-1,and IL-17 levels,along with a significant increase in IL-35 levels(P<0.05).Post-treatment,treatment group demonstrated significantly lower BODE index,traditional Chinese medicine syndrome scores,MCP-1,and IL-17 levels,as well as higher IL-35 levels compared to control group(P<0.05).Conclusion The combined application of Liuzijue with traditional Chinese medicine external therapy was shown to improve BODE index and traditional Chinese medicine syndrome scores in patients with stable COPD,while effectively reducing pro-inflammatory factors MCP-1 and IL-17 and elevating anti-inflammatory factor IL-35 levels.
作者
张安安
胡丹丹
张锦梅
张心如
ZHANG An’an;HU Dandan;ZHANG Jinmei;ZHANG Xinru(The Third Clinical Medical College,Zhejiang Chinese Medical University,Hangzhou 310053,Zhejiang,China;Department of Respiratory and Critical Care Medicine,the Third Affiliated Hospital of Zhejiang Chinese Medical University,Hangzhou 310005,Zhejiang,China)
出处
《中国现代医生》
2025年第24期12-16,共5页
China Modern Doctor
基金
浙江省中医药科技计划重点项目(2021ZZ018)。
关键词
慢性阻塞性肺疾病
六字诀
中医外治
炎症因子
Chronic obstructive pulmonary disease
Liuzijue
Traditional Chinese medicine external therapy
Inflammation
