摘要
目的:探讨解毒降糖复瘫汤联合针灸在脑梗死急性期合并糖尿病患者(气虚血瘀型)治疗中的应用价值。方法:所有脑梗死急性期合并糖尿病患者(气虚血瘀型)均于2020年10月至2022年9月在南昌市洪都中医院就诊并随机分为两组,两组均69例,对照组采用西医常规治疗,观察组联合解毒降糖复瘫汤及针灸治疗,治疗2周后比较疗效。结果:与治疗前比较,治疗后两组血清超氧化物歧化酶(SOD)、血管内皮生长因子(VEGF)、脑源性神经营养因子(BDNF)均升高;血清基质金属蛋白酶-9(MMP-9)、IL-6、空腹血糖(FBG)、餐后2 h血糖(2 h PG)、糖化血红蛋白(HbA1c)均降低;Barthel指数(BI)均升高,改良Rankin评分(mRS)、神经功能缺损评分(NIHSS)均降低(P<0.05)。与对照组比较,治疗后观察组血清SOD、VEGF、BDNF等指标水平更高;MMP-9、IL-6、FBG、2 h PG、HbA1c更低;BI更高,mRS、NIHSS更低,差异具有统计学意义(P<0.05);观察组总有效率为94.20%(65/69),高于对照组的84.06%(58/69)(P<0.05)。结论:联合解毒降糖复瘫汤及针灸治疗有助于促进脑梗死急性期合并糖尿病患者(气虚血瘀型)脑部供血,纠正氧化应激失衡,调控血糖水平,提高临床疗效。
Objective:To explore the application value of Jiedu Jiangtang Futan Decoction combined with acupuncture and moxibustion in the treatment of acute cerebral infarction patients with diabetes(qi deficiency and blood stasis type).Methods:All pa-tients with acute cerebral infarction complicated with diabetes(type of qi deficiency and blood stasis)were treated in Hongdu Tradi-tional Chinese Medicine Hospital from October 2020 to September 2022 and randomly divided into two groups,with 69 cases in each group.The control group was treated with conventional western medicine,and the observation group was treated with Jiedu Jiangtang Futan Decoction and acupuncture and moxibustion,and the efficacy was compared after two weeks of treatment.Results:Compared with before treatment,the serum levels of superoxide dismutase(SOD),vascular endothelial growth factor(VEGF)and brain-derived neurotrophic factor(BDNF)were increased in the two groups after treatment.The levels of serum matrix metalloproteinase-9(MMP-9),IL-6,fasting blood glucose(FBG),2-hour postprandial glucose(2 h PG)and glycated hemoglobin(HbA1c)were decreased.The Barthel index(BI)was increased,and the modified Rankin score(mRS)and National Institutes of Health Stroke Scale(NIHSS)were decreased(P<0.05).Compared with the control group,the levels of SOD,VEGF,BDNF and other indicators in the observation group were higher after treatment.The levels of MMP-9,IL-6,FBG,2 h PG and HbA1c were lower.BI was higher,mRS and NIHSS were lower,the difference were statistically significant(P<0.05).The total effective rate in the observation group was 94.20%(65/69),higher than 84.06%(58/69)in the control group(P<0.05).Conclusion:For patients with acute cerebral infarction complicated with diabetes(type of qi deficiency and blood stasis),the combination of Jiedu Jiangtang Futan Decoction and acupuncture and moxibustion treatment is helpful to promote blood supply to the brain,correct the imbalance of oxidative stress,regulate blood sugar level and improve clinical efficacy.
作者
彭天忠
黄学娣
林星镇
袁娟
周峰
胡思彦
朱满华
PENG Tianzhong;HUANG Xuedi;LIN Xingzhen;YUAN Juan;ZHOU Feng;HU Siyan;ZHU Manhua(Department of Rehabilitation Medicine,Hongdu Traditional Chinese Medicine Hospital,Nanchang City,Nanchang 330008,China;Department of Pharmacy,Jiangxi Integrated Traditional Chinese and Western Medicine Hospital,Nanchang 330003,China)
出处
《中国免疫学杂志》
北大核心
2025年第8期1890-1894,1900,共6页
Chinese Journal of Immunology
基金
江西省中医药中青年骨干人才培养项目[赣中医药科教字(2020)5号]
江西省卫生计生委科技计划(20187062)。
关键词
解毒降糖复瘫汤
针灸
脑梗死急性期合并糖尿病
气虚血瘀型
IL-6
MMP-9
VEGF
氧化应激
Jiedu Jiangtang Futan Decoction
Acupuncture and moxibustion
Acute cerebral infarction complicated with dia-betes
Qi deficiency and blood stasis type
IL-6
MMP-9
VEGF
Oxidative stress
