摘要
目的分析总结孟德尔随机化(MR)研究在我国医学领域应用情况,探讨优势、注意事项、热点动向。方法通过检索2006-2024年中国知网、万方数据库、维普数据库期刊论文,运用CiteSpace软件绘制可视化图谱,对发文量、期刊类型、作者、机构、关键词进行展示,结合国外研究情况进行综合分析。结果共分析期刊文献801篇,作者243名,第一篇中文MR论文发表于2006年,2023年开始发文量成倍增长,刊载量排名前10位期刊中双核心期刊及以上占比达到66.2%,论文质量较高;薛付忠,毛盈颖、叶丁团队最为活跃,中医院校和部分综合性大学的公共卫生学院开展工作突出;共得出327个关键词,形成16个关键词聚类,研究热点以冠心病、糖尿病、肥胖症、肿瘤、肠道疾病、抑郁症、生活习惯为主。MR理论探讨较薄弱,主要涉及8篇论文。结论面对论文数量成倍增长,需要警惕保证论文质量及研究意义;热点方向会随着数据库日益丰富而拓展,深化MR理论探讨和方法创新,借助国际上现有研究规避方案设计的缺陷,借助组学等生物学新方法开展更全面深入的研究。
Objective To analyze and summarize the application of Mendelian randomization(MR)research in Chinese medical field,and to discuss the advantages,cautions,and hot trends.Methods By searching journal articles from 2006 to 2024 in China Knowledge Network,Wanfang Database,and VIP Database,and using CiteSpace software to draw visual maps to display the number of publications,journal types,authors,institutions,and keywords,and to conduct a comprehensive analysis by combining with foreign research.Results A total of 801 journal papers with 243 authors were analyzed;the first Chinese MR paper was published in 2006,and the number of publications increased exponentially from 2023 onwards;the proportion of double core journals and above in the top 10 journals ranked by the number of publications reached 66.2%,and the quality of the papers was higher;the team of XUE Fuzhong,MAO Yingying and YE Ding was the most active,and the schools of public health of TCM colleges and universities and some universities of general public health carried out Outstanding work;a total of 327 keywords were derived,forming 16 keyword clusters,and the research hotspots were dominated by coronary heart disease,diabetes mellitus,obesity,tumors,intestinal disorders,depression,and living habits.the theoretical exploration of MR was weak,mainly involving 8 papers.Conclusion In the light of the proliferation of articles,it is imperative to maintain vigilance in ensuring the quality and significance of research publications.The hotspot direction will be expanded with the increasing abundance of the database,to deepen the exploration of MR theories and methodological innovations,to avoid the shortcomings of the program design by means of the existing research in the international community,and to carry out more comprehensive and in-depth research with the help of the new methods in biology,such as g enomics.
作者
吴松立
陈思
杨丹
安艳辉
罗杨
李菊敏
WU Songli;CHEN Si;YANG Dan;AN Yanhui;LUO Yang;LI Jumin(The Thirteenth People’s Hospital of Chongqing,Chongqing 400053,China;Chongqing Medical University,Chongqing 400016,China;University-Town Hospital of Chongqing Medical University,Chongqing 401331,China;The First Hospital of Fangshan District,Beijing 102400,China;Chongqing Traditional Chinese Medicine Hospital,Chongqing 400021,China;Suzhou hospital of Traditional Chinese Medicine,Nanjing University of Chinese Medicine,Jiangsu,Suzhou 215000,China)
出处
《中国医药科学》
2025年第15期62-66,136,共6页
China Medicine And Pharmacy
基金
重庆市科卫联合中医药科研项目(2023QNXM055)
苏州市中西医结合科研基金项目(SKYD2023260)。
